Effects of Bifidobacterium on metabolic parameters in overweight or obesity adults: a systematic review and meta-analysis.

IF 4 2区生物学 Q2 MICROBIOLOGY

Frontiers in Microbiology Pub Date : 2025-09-25 eCollection Date: 2025-01-01 DOI:10.3389/fmicb.2025.1633434

Junmei Huang, Hao Cheng

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引用次数: 0

Abstract

Objective: This study endeavors to elucidate how Bifidobacteria supplementation affects metabolic parameters among overweight or obese populations.

Methods: A systematic review and meta-analysis were carried out leveraging PubMed, Embase, Cochrane Library, and Web of Science. Merely randomized controlled trials (RCTs) were included.

Results: 21 RCTs were encompassed for our final analysis. Bifidobacteria supplementation was effective in weight management for overweight or obese patients. The experimental group receiving Bifidobacteria exhibited a marked decrease in weight (WMD: -0.607 kg; 95% CI: -0.910, -0.303, I² = 11.9%) and BMI (WMD: -0.214 kg/m²; 95% CI: -0.259, -0.169, I² = 4.1%) in contrast to the control, although the significant effect was not noted on WC. Moreover, while Bifidobacteria supplementation led to no marked drop in FBG or HbA1c, it improved the insulin (SMD: -0.268; 95% CI: -0.470, -0.066, I² = 5.4%). However, there were no evident variations in TC, TG, HDL-C, or LDL-C across groups.

Conclusion: Our study findings confirmed that Bifidobacteria contributes to a slight reduction in weight and BMI among the overweight or obese populations, making it a potential adjunctive approach for weight management. Furthermore, it may help regulate insulin levels, though its impact on hyperglycemia and hyperlipidemia remains limited.

Systematic review registration: https://www.crd.york.ac.uk/PROSPERO. Registration No. CRD42025635324.

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双歧杆菌对超重或肥胖成人代谢参数的影响：一项系统综述和荟萃分析。

目的：本研究旨在阐明补充双歧杆菌如何影响超重或肥胖人群的代谢参数。方法：利用PubMed、Embase、Cochrane Library和Web of Science进行系统综述和荟萃分析。仅纳入随机对照试验（rct）。结果：21项随机对照试验纳入我们的最终分析。补充双歧杆菌对超重或肥胖患者的体重管理有效。与对照组相比，接受双歧杆菌治疗的实验组体重（WMD: -0.607 kg; 95% CI: -0.910, -0.303, I2 = 11.9%）和BMI （WMD: -0.214 kg/m2; 95% CI: -0.259, -0.169, I2 = 4.1%）显著降低，但对WC没有显著影响。此外，虽然补充双歧杆菌没有导致FBG或HbA1c的显著下降，但它改善了胰岛素（SMD: -0.268; 95% CI: -0.470, -0.066, I2 = 5.4%）。然而，各组之间TC、TG、HDL-C或LDL-C没有明显差异。结论：我们的研究结果证实，双歧杆菌有助于在超重或肥胖人群中轻微降低体重和BMI，使其成为体重管理的潜在辅助方法。此外，它可能有助于调节胰岛素水平，尽管它对高血糖和高脂血症的影响仍然有限。系统评审注册：https://www.crd.york.ac.uk/PROSPERO。没有注册。CRD42025635324。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Microbiology MICROBIOLOGY-

CiteScore

7.70

自引率

9.60%

发文量

4837

审稿时长

14 weeks

期刊介绍： Frontiers in Microbiology is a leading journal in its field, publishing rigorously peer-reviewed research across the entire spectrum of microbiology. Field Chief Editor Martin G. Klotz at Washington State University is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.