Effects of exercise interventions on breast cancer-related endogenous hormones in premenopausal and postmenopausal women: a systematic review and meta-analysis.
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Abstract
Background: Breast cancer is the most common malignant tumor among women, and its etiology and progression are closely associated with hormone levels. Hormone levels undergo significant changes in pre- and postmenopausal women. Exercise intervention, as a safe and effective lifestyle intervention, may modulate hormone levels and affect the incidence and prognosis of breast cancer.
Methods: Three databases were searched to identify relevant literature for this study, which included 11 studies in the meta-analysis. The impact of an exercise intervention on breast cancer-related hormones was evaluated, including estrone, estradiol, free estradiol, testosterone, SHBG, 2-OH E1, 16a-OH E1, androstenedione, testosterone, and free testosterone, in both pre- and postmenopausal women.
Results: The study findings suggest that the impact of exercise intervention on breast cancer-related hormones in pre- and postmenopausal women may not be significant. This lack of significance could be linked to differences in exercise intervention protocols, study quality, changes in body fat percentage post-exercise, and the specific characteristics of the populations (pre- and postmenopausal) analyzed in the studies. However, subgroup analyses suggested that exercise intervention might have a significant effect on certain estrogens in postmenopausal women and women who engaged in exercise for more than 6 months.
Conclusion: The impact of exercise intervention on hormone levels may be influenced by body fat and menopausal status, as well as the duration of follow-up. Further high-quality and standardized studies are needed to confirm and enhance the findings of this research.
期刊介绍：
Frontiers in Physiology is a leading journal in its field, publishing rigorously peer-reviewed research on the physiology of living systems, from the subcellular and molecular domains to the intact organism, and its interaction with the environment. Field Chief Editor George E. Billman at the Ohio State University Columbus is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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