Exploring Recent Advances in Colon-targeted Drug Delivery Systems: from Traditional Methods to Advanced Technologies.

IF 4.1 Q1 Medicine

Current Gastroenterology Reports Pub Date : 2025-10-13 DOI:10.1007/s11894-025-01019-w

Nidhi Agrawal, Mohammad Akbar Siddiqui, Sakshi Gupta, Meenakshi Jaiswal, S K Lanjhiyana

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引用次数: 0

Abstract

Purpose of review: This review examines various colon-targeted drug delivery systems (CTDDS) and their implications for the treatment of colonic disorders.

Recent findings: Recent studies have demonstrated substantial advancements in CTDDS by the development of pH-dependent, enzyme-responsive, and time-controlled formulations designed for enhancing site-specific delivery and reducing systemic adverse effects. Advanced methodologies, such as ligand or receptor-mediated targeting and multifunctional systems that incorporate various triggering mechanisms, are demonstrating encouraging outcomes in improving therapeutic efficacy. Furthermore, innovative methods like pressure, osmotic-controlled systems, and 3D printing technologies are also being explored for their ability to ensure precise drug release in the colonic region. CTDDS enables localized, controlled therapy, which has the potential to enhance colonic disease outcomes. Integrating the knowledge of the colon's physiology with new delivery technologies may help future research and facilitate the development of more effective treatments.

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探索结肠靶向药物输送系统的最新进展：从传统方法到先进技术。

综述目的：本文综述了各种结肠靶向药物输送系统（CTDDS）及其在结肠疾病治疗中的意义。最近的发现：最近的研究表明，通过ph依赖性、酶反应性和时间控制配方的开发，CTDDS取得了实质性进展，这些配方旨在增强部位特异性给药和减少全身不良反应。先进的方法，如配体或受体介导的靶向和包含各种触发机制的多功能系统，在提高治疗效果方面显示出令人鼓舞的结果。此外，压力、渗透控制系统和3D打印技术等创新方法也在探索中，因为它们能够确保药物在结肠区域的精确释放。CTDDS能够实现局部控制治疗，这有可能提高结肠疾病的预后。将结肠生理学知识与新的输送技术相结合，可能有助于未来的研究，并促进更有效治疗方法的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Gastroenterology Reports Medicine-Gastroenterology

CiteScore

7.80

自引率

0.00%

发文量

期刊介绍： As the field of gastroenterology and hepatology rapidly evolves, the wealth of published literature can be overwhelming. The aim of the journal is to help readers stay abreast of such advances by offering authoritative, systematic reviews by leading experts. We accomplish this aim by appointing Section Editors who invite international experts to contribute review articles that highlight recent developments and important papers published in the past year. Major topics in gastroenterology are covered, including pediatric gastroenterology, neuromuscular disorders, infections, nutrition, and inflammatory bowel disease. These reviews provide clear, insightful summaries of expert perspectives relevant to clinical practice. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.