Excess energy intake causally increases the blood pressure and hypertension risk: A Two Sample Mendelian Randomization Analysis.

IF 2.6 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-10-10 DOI:10.1016/j.clnesp.2025.10.001

Farshad Teymoori, Mahdi Akbarzadeh, Niloufar Saber, Mitra Kazemi Jahromi, Danial Habibi, Hossein Farhadnejad, Maryam Zarkesh, Parvin Mirmiran, Mohammadreza Vafa, Maryam S Daneshpour

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引用次数: 0

Abstract

Background: /Aim: The impact of excess energy intake on blood pressure(BP) and hypertension(HTN) has not been extensively studied. This study aimed to evaluate the causal link between energy intake and systolic and diastolic BP(SBP and DBP) and HTN, using a Mendelian randomization(MR) approach.

Methods: We conducted an MR analysis using summary statistics from large-scale genome-wide association studies(GWAS) datasets of European ancestry. Several MR methods were applied, including inverse-variance weighted(IVW), weighted median and mode, and MR-Egger regression. Genetic variants associated with energy intake were obtained from a published GWAS of the UK Biobank(N=64,979). GWAS datasets for SBP, DBP, and HTN included 436,419; 436,424; and 361,194 individuals (1,237 cases and 359,957 controls), respectively, all from the UK Biobank. Effect estimates were reported as beta coefficients(β) with 95% confidence intervals(CIs) for continuous outcomes and odds ratios(ORs) with 95% CIs for binary outcomes.

Results: The IVW analyses indicated that each SD increase in energy intake was causally associated with one SD increase in SBP(β=0.093,95%CI:0.027-0.160,P=0.006) and DBP(β=0.070,95%CI:0.014-0.126,P=0.014), based on 10 and 8 included SNPs, respectively. These significant associations were confirmed by the weighted median MR method for SBP(β=0.096,95%CI:0.032-0.169,P=0.012) and DBP(β=0.077,95%CI:0.006-0.148,P=0.044). Furthermore, a causal relationship between energy intake and HTN was observed using the IVW(OR=1.004,95%CI:1.002-1.006,P=0.012) and the MR Egger method(OR=1.012,95%CI:1.004-1.020,P=0.045), based on 9 included SNPs. No evidence of weak instrument bias, heterogeneity, or horizontal pleiotropy was detected. The significant findings were consistent across most applied MR methods.

Conclusions: Our findings support a direct causal relationship between excess energy intake and both BP and HTN.

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过量的能量摄入会增加血压和高血压的风险：两样本孟德尔随机化分析。

背景/目的：能量摄入过量对血压（BP）和高血压（HTN）的影响尚未得到广泛研究。本研究旨在评估能量摄入与收缩压和舒张压（SBP和DBP）和HTN之间的因果关系，采用孟德尔随机化（MR）方法。方法：我们使用大规模全基因组关联研究（GWAS）欧洲血统数据集的汇总统计数据进行MR分析。使用了几种MR方法，包括反方差加权（IVW），加权中位数和模式以及MR- egger回归。与能量摄入相关的遗传变异来自英国生物银行（UK Biobank）已发表的GWAS （N=64,979）。收缩压、舒张压和HTN的GWAS数据集包括436,419；436424年;和361194人（分别为1237例和359957例对照），均来自英国生物银行。效果估计以连续结局的95%置信区间（CIs）的β系数（β）和二元结局的95% ci的优势比（ORs）报告。结果：IVW分析显示，能量摄入每增加一个SD，收缩压（β=0.093,95%CI:0.027-0.160，P=0.006）和舒张压（β=0.070,95%CI:0.014-0.126，P=0.014）分别增加一个SD，分别基于10和8个纳入的snp。加权MR中位数法证实了收缩压（β=0.096,95%CI:0.032-0.169，P=0.012）和舒张压（β=0.077,95%CI:0.006-0.148，P=0.044）的显著相关性。此外，基于9个纳入的snp，采用IVW（OR=1.004,95%CI:1.002-1.006，P=0.012）和MR Egger法（OR=1.012,95%CI:1.004-1.020，P=0.045）观察能量摄入与HTN之间的因果关系。未发现弱仪器偏倚、异质性或水平多效性的证据。在大多数应用的MR方法中，重要的发现是一致的。结论：我们的研究结果支持过量能量摄入与BP和HTN之间的直接因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.