Rinaldo Bellomo: A clinician with a passion for preclinical research

IF 1.7 4区医学 Q3 CRITICAL CARE MEDICINE

Critical Care and Resuscitation Pub Date : 2025-09-01 DOI:10.1016/j.ccrj.2025.100128

Clive N. May PhD , Yugeesh R. Lankadeva PhD , Shailesh Bihari PhD

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引用次数: 0

Abstract

Professor Rinaldo Bellomo was a pioneer in intensive care medicine whose influence extended beyond clinical trials to preclinical and translational research. His long-standing collaboration with the Florey Institute established ovine sepsis models that overturned dogma, demonstrating that septic acute kidney injury can occur despite increased renal blood flow, and clarifying the effects of fluids, noradrenaline, vasopressin, and angiotensin II. These studies advanced understanding of renal medullary hypoperfusion and hypoxia, guided antioxidant strategies, and inspired clinical investigation of megadose sodium ascorbate. Rinaldo also championed integration of preclinical science into the ANZICS Clinical Trials Group, legitimising dedicated sessions, fostering collaboration, and ensuring basic discoveries informed hypothesis-driven clinical trials. A gifted mentor and communicator, he inspired generations of researchers with his curiosity, humility, and passion for physiology. His legacy as both clinician and scientist underscores the enduring value of discovery research in advancing critical care.

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里纳尔多·贝洛莫：一位对临床前研究充满热情的临床医生

Rinaldo Bellomo教授是重症监护医学的先驱，其影响从临床试验扩展到临床前和转化研究。他与弗洛里研究所的长期合作建立了羊脓毒症模型，推翻了以往的教条，证明尽管肾血流量增加，脓毒性急性肾损伤仍可能发生，并阐明了液体、去甲肾上腺素、血管加压素和血管紧张素II的作用。这些研究促进了对肾髓质灌注不足和缺氧的认识，指导了抗氧化策略，并启发了大剂量抗坏血酸钠的临床研究。Rinaldo还倡导将临床前科学纳入ANZICS临床试验小组，使专门会议合法化，促进合作，并确保基本发现为假设驱动的临床试验提供信息。他是一位天才导师和沟通者，他的好奇心、谦逊和对生理学的热情激励了一代又一代的研究人员。他作为临床医生和科学家的遗产强调了发现研究在推进重症监护方面的持久价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Care and Resuscitation CRITICAL CARE MEDICINE-

CiteScore

7.70

自引率

3.40%

发文量

审稿时长

>12 weeks

期刊介绍： ritical Care and Resuscitation (CC&R) is the official scientific journal of the College of Intensive Care Medicine (CICM). The Journal is a quarterly publication (ISSN 1441-2772) with original articles of scientific and clinical interest in the specialities of Critical Care, Intensive Care, Anaesthesia, Emergency Medicine and related disciplines. The Journal is received by all Fellows and trainees, along with an increasing number of subscribers from around the world. The CC&R Journal currently has an impact factor of 3.3, placing it in 8th position in world critical care journals and in first position in the world outside the USA and Europe.