Run Zhang, Xinwang Chen, Mengyu Wang, Wenming Chu, Lihua Wu, Jing Gao, Peidong Liu, Ce Shi, Liyuan Liu, Bingzhen Li, Miaomiao Ji, Yayong He
{"title":"[<i>Tiaowei Jiannao</i> acupuncture for post-ischemic stroke insomnia: a randomized controlled trial].","authors":"Run Zhang, Xinwang Chen, Mengyu Wang, Wenming Chu, Lihua Wu, Jing Gao, Peidong Liu, Ce Shi, Liyuan Liu, Bingzhen Li, Miaomiao Ji, Yayong He","doi":"10.13703/j.0255-2930.20240417-k0006","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To observe the efficacy and safety of <i>Tiaowei Jiannao</i> acupuncture (acupuncture for regulating defensive <i>qi</i> and nourishing brain) for post-ischemic stroke insomnia (PISI).</p><p><strong>Methods: </strong>A total of 96 patients with PISI were randomized into an acupuncture group (32 cases, 1 case was excluded), a medication group (32 cases, 1 case dropped out, 1 case was excluded) and a sham-acupuncture group (32 cases, 1 case dropped out, 1 case was excluded). In the acupuncture group, <i>Tiaowei Jiannao</i> acupuncture was applied at bilateral Shenmai (BL62), Zhaohai (KI6), Hegu (LI4), Taichong (LR3), and Baihui (GV20), Sishencong (EX-HN1), Yintang (GV24<sup>+</sup>), Shenting (GV24), once a day, 1-day interval was taken after 6-day treatment, for 3 weeks totally. In the medication group, eszopiclone tablet was given orally, 1-3 mg a time, once a day for 3 weeks. In the sham-acupuncture group, non-invasive sham acupuncture was applied, the acupoint selection, frequency and course of treatment were the same as the acupuncture group. Before treatment, after 2,3 weeks of treatment, the scores of Pittsburgh sleep quality index (PSQI), self-rating sleep scale (SRSS), National Institutes of Health Stroke scale (NIHSS), Hamilton depression scale-17 (HAMD-17) were observed; before and after treatment, the sleep parameters were recorded using polysomnography (PSG); and the efficacy and safety were evaluated after treatment in the 3 groups.</p><p><strong>Results: </strong>After 2,3 weeks of treatment, the scores of PSQI, HAMD-17 and SRSS in the acupuncture group and the medication group, as well as the SRSS scores in the sham-acupuncture group were decreased compared with those before treatment (<i>P</i><0.05); after 2 weeks of treatment, the NIHSS score in the acupuncture group was decreased compared with that before treatment (<i>P</i><0.05); after 3 weeks of treatment, the NIHSS scores in the acupuncture group, the medication group and the sham-acupuncture group were decreased compared with those before treatment (<i>P</i><0.05). After 3 weeks of treatment, the scores of PSQI, SRSS, HAMD-17 and NIHSS in the acupuncture group and the medication group, as well as the NIHSS score in the sham-acupuncture group were decreased compared with those after 2 weeks of treatment (<i>P</i><0.05). After 2,3 weeks of treatment, the scores of PSQI, SRSS and HAMD-17 in the acupuncture group and the medication group were lower than those in the sham-acupuncture group (<i>P</i><0.05), the NIHSS scores in the acupuncture group were lower than those in the medication group and the sham-acupuncture group (<i>P</i><0.05); after 3 weeks of treatment, HAMD-17 score in the acupuncture group was lower than that in the medication group (<i>P</i><0.05), the NIHSS score in the medication group was lower than that in the sham-acupuncture group (<i>P</i><0.05). Compared before treatment, after treatment, the total sleep time was prolonged (<i>P</i><0.05), the wake after sleep onset, sleep latency, and non-rapid eye movement (NREM) sleep latency were shortened (<i>P</i><0.05), the sleep efficiency was improved (<i>P</i><0.05), the number of awakenings was reduced (<i>P</i><0.05), the percentage of rapid eye movement (REM%) and the percentage of NREM stage 1 (N1%) were decreased (<i>P</i><0.05), the percentage of NREM stage 2 (N2%) and the percentage of NREM stage 3 (N3%) were increased (<i>P</i><0.05) in the acupuncture group and the medication group; the sleep latency was shortened in the sham-acupuncture group (<i>P</i><0.05). After treatment, the PSG indexes in the acupuncture group and the medication group were superior to those in the sham-acupuncture group (<i>P</i><0.05); in the acupuncture group, the number of awakenings was less than that in the medication group (<i>P</i><0.05), the REM% and N1% were lower than those in the medication group (<i>P</i><0.05), the N2% and N3% were higher than those in the medication group (<i>P</i><0.05). The total effective rate were 93.5% (29/31) and 90.0% (27/30) in the acupuncture group and the medication group respectively, which were higher than 10.0% (3/30) in the sham-acupuncture group (<i>P</i><0.05). There was no serious adverse events in any of the 3 groups.</p><p><strong>Conclusion: </strong><i>Tiaowei Jiannao</i> acupuncture improves the insomnia symptoms in patients with ischemic stroke, improves the quality of sleep, increases the deep sleep, promotes the recovery of neurological function, and relieves the depression. It is effective and safe for the treatment of PISI.</p>","PeriodicalId":69903,"journal":{"name":"中国针灸","volume":"45 10","pages":"1405-1413"},"PeriodicalIF":0.0000,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国针灸","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.13703/j.0255-2930.20240417-k0006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/19 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To observe the efficacy and safety of Tiaowei Jiannao acupuncture (acupuncture for regulating defensive qi and nourishing brain) for post-ischemic stroke insomnia (PISI).
Methods: A total of 96 patients with PISI were randomized into an acupuncture group (32 cases, 1 case was excluded), a medication group (32 cases, 1 case dropped out, 1 case was excluded) and a sham-acupuncture group (32 cases, 1 case dropped out, 1 case was excluded). In the acupuncture group, Tiaowei Jiannao acupuncture was applied at bilateral Shenmai (BL62), Zhaohai (KI6), Hegu (LI4), Taichong (LR3), and Baihui (GV20), Sishencong (EX-HN1), Yintang (GV24+), Shenting (GV24), once a day, 1-day interval was taken after 6-day treatment, for 3 weeks totally. In the medication group, eszopiclone tablet was given orally, 1-3 mg a time, once a day for 3 weeks. In the sham-acupuncture group, non-invasive sham acupuncture was applied, the acupoint selection, frequency and course of treatment were the same as the acupuncture group. Before treatment, after 2,3 weeks of treatment, the scores of Pittsburgh sleep quality index (PSQI), self-rating sleep scale (SRSS), National Institutes of Health Stroke scale (NIHSS), Hamilton depression scale-17 (HAMD-17) were observed; before and after treatment, the sleep parameters were recorded using polysomnography (PSG); and the efficacy and safety were evaluated after treatment in the 3 groups.
Results: After 2,3 weeks of treatment, the scores of PSQI, HAMD-17 and SRSS in the acupuncture group and the medication group, as well as the SRSS scores in the sham-acupuncture group were decreased compared with those before treatment (P<0.05); after 2 weeks of treatment, the NIHSS score in the acupuncture group was decreased compared with that before treatment (P<0.05); after 3 weeks of treatment, the NIHSS scores in the acupuncture group, the medication group and the sham-acupuncture group were decreased compared with those before treatment (P<0.05). After 3 weeks of treatment, the scores of PSQI, SRSS, HAMD-17 and NIHSS in the acupuncture group and the medication group, as well as the NIHSS score in the sham-acupuncture group were decreased compared with those after 2 weeks of treatment (P<0.05). After 2,3 weeks of treatment, the scores of PSQI, SRSS and HAMD-17 in the acupuncture group and the medication group were lower than those in the sham-acupuncture group (P<0.05), the NIHSS scores in the acupuncture group were lower than those in the medication group and the sham-acupuncture group (P<0.05); after 3 weeks of treatment, HAMD-17 score in the acupuncture group was lower than that in the medication group (P<0.05), the NIHSS score in the medication group was lower than that in the sham-acupuncture group (P<0.05). Compared before treatment, after treatment, the total sleep time was prolonged (P<0.05), the wake after sleep onset, sleep latency, and non-rapid eye movement (NREM) sleep latency were shortened (P<0.05), the sleep efficiency was improved (P<0.05), the number of awakenings was reduced (P<0.05), the percentage of rapid eye movement (REM%) and the percentage of NREM stage 1 (N1%) were decreased (P<0.05), the percentage of NREM stage 2 (N2%) and the percentage of NREM stage 3 (N3%) were increased (P<0.05) in the acupuncture group and the medication group; the sleep latency was shortened in the sham-acupuncture group (P<0.05). After treatment, the PSG indexes in the acupuncture group and the medication group were superior to those in the sham-acupuncture group (P<0.05); in the acupuncture group, the number of awakenings was less than that in the medication group (P<0.05), the REM% and N1% were lower than those in the medication group (P<0.05), the N2% and N3% were higher than those in the medication group (P<0.05). The total effective rate were 93.5% (29/31) and 90.0% (27/30) in the acupuncture group and the medication group respectively, which were higher than 10.0% (3/30) in the sham-acupuncture group (P<0.05). There was no serious adverse events in any of the 3 groups.
Conclusion: Tiaowei Jiannao acupuncture improves the insomnia symptoms in patients with ischemic stroke, improves the quality of sleep, increases the deep sleep, promotes the recovery of neurological function, and relieves the depression. It is effective and safe for the treatment of PISI.
期刊介绍：
Chinese Acupuncture and Moxibustion (founded in 1981, monthly) is an authoritative academic journal of acupuncture and moxibustion under the supervision of China Association for Science and Technology and co-sponsored by Chinese Acupuncture and Moxibustion Society and Institute of Acupuncture and Moxibustion of China Academy of Traditional Chinese Medicine. It is recognised as a core journal of Chinese science and technology, a core journal of Chinese language, and is included in the core journals of China Science Citation Database, as well as being included in MEDLINE and other international well-known medical index databases. The journal adheres to the tenet of ‘improving, taking into account the popularity, colourful and realistic’, and provides valuable learning and communication opportunities for the majority of acupuncture and moxibustion clinical and scientific research workers, and plays an important role in the domestic and international publicity and promotion of acupuncture and moxibustion disciplines.
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