Propensity score analysis of stented vs rapid deployment aortic bioprostheses in patients with small aortic annulus.

Abstract

Objectives: Haemodynamic studies have demonstrated the excellent performance of rapid-deployment (RD) valves. This retrospective single-center study aimed to compare early and medium-term outcomes of RD bioprostheses versus conventional stented valves in patients with small aortic annuli.

Methods: We included patients who underwent isolated or combined surgical aortic valve replacement (SAVR) with Magna Ease (ME) and Intuity (Edwards Lifesciences, Irvine, CA) sizes 19 and 21 at our institution between June 2016 and March 2022. Follow-up was conducted through scheduled visits and echocardiograms at the study site, or via telephonic interviews with patients and/or referring cardiologists. A propensity score weighting analysis was performed to account for baseline differences between the two cohorts.

Results: A total of 666 consecutive patients underwent SAVR with the two devices. ME was implanted in 367 patients (55.1%), and Intuity in 299 (44.9%). ME size 19 or 21 was used in 105 patients (35.1%), and Intuity size 19 or 21 in 115 (31.3%). 220 patients were our study population. There were no significant differences in postoperative complications. Intuity demonstrated significantly lower gradients overall (mean gradients: 12 mmHg vs 16 mmHg, p < 0.001), and for size 21 (mean gradients: 12 mmHg vs 15 mmHg, p < 0.001). Mid-term survival and rehospitalization rates were similar between the two devices (5-year rehospitalization rate: 17% ME vs 20.9% Intuity, p = 0.57; 5-year survival: 81.9% ME vs 88% Intuity, p = 0.761).

Conclusions: In patients with small aortic annuli, RD bioprostheses provide superior haemodynamic outcomes compared to conventional stented valves. However, perioperative outcomes, mid-term survival, and rehospitalization rates are similar between the two devices.