{"title":"Central line infections in a haematology-oncology patient associated with Bacillus containing cleaning spray.","authors":"Julie Messiaen, Veroniek Saegeman, Melissa Depypere, Veerle Cossey, Marleen Renard, Annette Schuermans","doi":"10.1016/j.jhin.2025.09.007","DOIUrl":null,"url":null,"abstract":"<p><p>Haemato-oncological patients are susceptible to infections due to aplasia. We describe an adolescent with a history of a relapse precursor B-cell acute lymphoblastic leukaemia, who experienced a second leukaemia after CAR-T-cell therapy with a lineage switch to acute myeloid leukaemia. He experienced events of central-line associated bloodstream infections with Bacillus species, requiring long-term broad spectrum antibiotics, central venous line replacements and removal of a port catheter. We identified a commercially available 'synbiotic spray', containing Bacillus strains as the likely source of contamination. We advocate for public health warnings regarding using household probiotic cleaning products in environments with immunocompromized individuals.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Hospital Infection","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jhin.2025.09.007","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Haemato-oncological patients are susceptible to infections due to aplasia. We describe an adolescent with a history of a relapse precursor B-cell acute lymphoblastic leukaemia, who experienced a second leukaemia after CAR-T-cell therapy with a lineage switch to acute myeloid leukaemia. He experienced events of central-line associated bloodstream infections with Bacillus species, requiring long-term broad spectrum antibiotics, central venous line replacements and removal of a port catheter. We identified a commercially available 'synbiotic spray', containing Bacillus strains as the likely source of contamination. We advocate for public health warnings regarding using household probiotic cleaning products in environments with immunocompromized individuals.
期刊介绍：
The Journal of Hospital Infection is the editorially independent scientific publication of the Healthcare Infection Society. The aim of the Journal is to publish high quality research and information relating to infection prevention and control that is relevant to an international audience.
The Journal welcomes submissions that relate to all aspects of infection prevention and control in healthcare settings. This includes submissions that:
provide new insight into the epidemiology, surveillance, or prevention and control of healthcare-associated infections and antimicrobial resistance in healthcare settings;
provide new insight into cleaning, disinfection and decontamination;
provide new insight into the design of healthcare premises;
describe novel aspects of outbreaks of infection;
throw light on techniques for effective antimicrobial stewardship;
describe novel techniques (laboratory-based or point of care) for the detection of infection or antimicrobial resistance in the healthcare setting, particularly if these can be used to facilitate infection prevention and control;
improve understanding of the motivations of safe healthcare behaviour, or describe techniques for achieving behavioural and cultural change;
improve understanding of the use of IT systems in infection surveillance and prevention and control.
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