Association between IL-6 gene polymorphisms and susceptibility to Parkinson's disease.

IF 1.3 4区医学 Q2 ANTHROPOLOGY

Annals of Human Biology Pub Date : 2025-12-01 Epub Date: 2025-10-10 DOI:10.1080/03014460.2025.2569473

Jinzhao Gao, Zihan Wang, Kunpeng Qin, Yilin Wang, Qiqing He, Yuting Zhou, Anmu Xie, Binghui Hou

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引用次数: 0

Abstract

Background: The multifunctional cytokine interleukin 6 (IL-6) and its single nucleotide polymorphisms (SNPs) may influence the risk of Parkinson's disease (PD).

Aim: To investigate the association between specific SNPs in the IL-6 gene and susceptibility to PD in the northern Chinese Han population.

Subjects and methods: A total of 800 Chinese Han subjects were enrolled in this case-control study, including 400 PD patients and 400 healthy controls. Peripheral blood of all subjects was collected for DNA extraction and genotyped for selected SNPs (rs1800796, rs1524107) using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Results: We found significant differences in the allele (C vs. G, p = 0.002) and CC genotype (p = 0.012) of rs1800796 in the PD group compared to the control group. In addition, significant differences were observed between the two groups in both dominant and additive models (p_dominant=0.046, p_additive=0.025). In further subgroup analysis, compared with the matched male control group, the frequency of CC genotype in male PD was higher (p = 0.035), and allele C may increase the risk of disease (p = 0.012). Similarly, when compared to the healthy control group, patients in the late-onset Parkinson's Disease (LOPD) group also exhibited a higher frequency of CC genotype and C allele (p_genotype = 0.015, p_alle = 0.004).

Conclusion: The rs1800796 polymorphism of the IL-6 gene may be associated with susceptibility to PD in the northern Chinese Han population.

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IL-6基因多态性与帕金森病易感性的关系

背景：多功能细胞因子白介素6 （IL-6）及其单核苷酸多态性（SNPs）可能影响帕金森病（PD）的发病风险。目的：探讨中国北方汉族人群IL-6基因特异性snp与PD易感性的关系。对象和方法：本研究共纳入800名汉族受试者，其中400名PD患者和400名健康对照。收集所有受试者的外周血进行DNA提取，并采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）对选择的snp （rs1800796、rs1524107）进行基因分型。结果：PD组rs1800796的等位基因（C vs. G, p = 0.002）和CC基因型（p = 0.012）与对照组相比有显著差异。此外，两组在显性模型和加性模型上均有显著差异（pdominant=0.046, padditive=0.025）。在进一步的亚组分析中，与匹配的男性对照组相比，男性PD中CC基因型的频率更高（p = 0.035），等位基因C可能增加疾病的风险（p = 0.012）。同样，与健康对照组相比，迟发性帕金森病（LOPD）组患者CC基因型和C等位基因的频率也更高（pgenotype = 0.015, palle = 0.004）。结论：IL-6基因rs1800796多态性可能与中国北方汉族人群PD易感性有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.