Sharon Jeong, Stephanie Bond, Warwick Bayly, Albert Sole-Guitart
{"title":"Laser fenestration of the dorsal pharyngeal recess does not correct experimentally induced dorsal nasopharyngeal collapse in horses.","authors":"Sharon Jeong, Stephanie Bond, Warwick Bayly, Albert Sole-Guitart","doi":"10.1111/vsu.70023","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To quantify the impact of experimentally induced dorsal nasopharyngeal collapse (NPC) on respiratory performance parameters and assess the efficacy of laser fenestration of the dorsal pharyngeal recess as a treatment option for experimentally induced NPC.</p><p><strong>Study design: </strong>Experimental interventional study.</p><p><strong>Animals: </strong>Six adult Standardbreds (one with naturally occurring disease).</p><p><strong>Methods: </strong>After an 8 week conditioning program, baseline parameters (V̇O<sub>2</sub>max, pharyngeal pressure, peak airflows, upper airway resistance) and dynamic endoscopy videos were collected in a high-speed treadmill test (T1). Dorsal NPC was induced via bilateral glossopharyngeal neurectomy, followed by data collection 2 weeks later (T2). Laser fenestration of the dorsal pharyngeal recess was then performed, followed by final data collection 3 weeks later (T3). Respiratory performance parameters for T1-T2, T2-T3, and T1-T3 were compared using paired t-test (p < .05) to evaluate the impact of NPC and efficacy of surgery. Dynamic endoscopy videos were subjectively graded and compared.</p><p><strong>Results: </strong>Moderate to severe dorsal NPC was successfully induced in five horses, with subjective improvement seen on dynamic endoscopy in 2/5 horses after fenestration. After NPC induction, V̇O<sub>2</sub>max, minute ventilation, and peak expiratory flow rates decreased by 63.5 mL/kg/min (p = .006), 78.8 L/min (p = .039) and 21.8 L/s (p = .013) respectively. Following fenestration, peak inspiratory flow rates decreased by 7.1 L/s (p = .03). In the naturally occurring case, V̇O<sub>2</sub>max increased by 12.9 mL/kg/min post-fenestration with subjective improvement in the degree of collapse.</p><p><strong>Conclusion: </strong>Respiratory performance parameters worsened following NPC induction in comparison with the baseline and did not improve following laser fenestration.</p><p><strong>Clinical significance: </strong>This experimental model did not support clinical application of laser salpingopharyngostomy to treat NPC.</p>","PeriodicalId":23667,"journal":{"name":"Veterinary Surgery","volume":" ","pages":""},"PeriodicalIF":1.3000,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary Surgery","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1111/vsu.70023","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To quantify the impact of experimentally induced dorsal nasopharyngeal collapse (NPC) on respiratory performance parameters and assess the efficacy of laser fenestration of the dorsal pharyngeal recess as a treatment option for experimentally induced NPC.
Study design: Experimental interventional study.
Animals: Six adult Standardbreds (one with naturally occurring disease).
Methods: After an 8 week conditioning program, baseline parameters (V̇O2max, pharyngeal pressure, peak airflows, upper airway resistance) and dynamic endoscopy videos were collected in a high-speed treadmill test (T1). Dorsal NPC was induced via bilateral glossopharyngeal neurectomy, followed by data collection 2 weeks later (T2). Laser fenestration of the dorsal pharyngeal recess was then performed, followed by final data collection 3 weeks later (T3). Respiratory performance parameters for T1-T2, T2-T3, and T1-T3 were compared using paired t-test (p < .05) to evaluate the impact of NPC and efficacy of surgery. Dynamic endoscopy videos were subjectively graded and compared.
Results: Moderate to severe dorsal NPC was successfully induced in five horses, with subjective improvement seen on dynamic endoscopy in 2/5 horses after fenestration. After NPC induction, V̇O2max, minute ventilation, and peak expiratory flow rates decreased by 63.5 mL/kg/min (p = .006), 78.8 L/min (p = .039) and 21.8 L/s (p = .013) respectively. Following fenestration, peak inspiratory flow rates decreased by 7.1 L/s (p = .03). In the naturally occurring case, V̇O2max increased by 12.9 mL/kg/min post-fenestration with subjective improvement in the degree of collapse.
Conclusion: Respiratory performance parameters worsened following NPC induction in comparison with the baseline and did not improve following laser fenestration.
Clinical significance: This experimental model did not support clinical application of laser salpingopharyngostomy to treat NPC.
期刊介绍：
Veterinary Surgery, the official publication of the American College of Veterinary Surgeons and European College of Veterinary Surgeons, is a source of up-to-date coverage of surgical and anesthetic management of animals, addressing significant problems in veterinary surgery with relevant case histories and observations.
It contains original, peer-reviewed articles that cover developments in veterinary surgery, and presents the most current review of the field, with timely articles on surgical techniques, diagnostic aims, care of infections, and advances in knowledge of metabolism as it affects the surgical patient. The journal places new developments in perspective, encompassing new concepts and peer commentary to help better understand and evaluate the surgical patient.
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