Francesco Martino, Sonia Ortiz-Peregrina, Miriam Casares-López, Pilar Granados-Delgado, José J Castro-Torres, Rosario G Anera
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引用次数: 0
Abstract
Purpose: To study the influence of different concentrations of vaporized cannabidiol (CBD; 0%, 15%, and 30%) on visual function and optical quality.
Methods: A randomized, crossover, double-blind, placebo-controlled, experimental study was conducted. A total of 30 participants with a mean age of 26.0 ± 6.3 years completed the study. Placebo (0 mg of CBD), 15% (16 mg of CBD), and 30% (32 mg of CBD) concentrations of CBD were employed. Visual function was evaluated through various tests, including pupil size, static and dynamic visual acuity, contrast sensitivity, dot motion detection, visual disturbance index (VDI), and stereoacuity. Optical quality was assessed by log(s), modulation transfer function (MTF) cutoff, objective scattering index (OSI), and Strehl ratio. Self-perceived visual effects were also recorded.
Results: There was no significant impairment of static and dynamic visual acuity. Contrast sensitivity was unaffected by CBD use. Mean dot motion detection showed no differences among the three concentrations. In optical quality, none of the parameters worsened under CBD use. No changes were observed for the VDI. In addition, no deterioration was observed for stereoacuity at distance or near. No changes in pupil size were found after CBD consumption.
Conclusions: This non-psychotropic CBD did not appear to adversely affect vision and seems to be a safe substance in the short term at the concentrations assessed.
Translational relevance: The use of this cannabinoid would not be dangerous for tasks that rely heavily on vision. This study could be useful and helpful for evidence-based decision-making for public health policy on its use.
期刊介绍：
Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO.
The journal covers a broad spectrum of work, including but not limited to:
Applications of stem cell technology for regenerative medicine,
Development of new animal models of human diseases,
Tissue bioengineering,
Chemical engineering to improve virus-based gene delivery,
Nanotechnology for drug delivery,
Design and synthesis of artificial extracellular matrices,
Development of a true microsurgical operating environment,
Refining data analysis algorithms to improve in vivo imaging technology,
Results of Phase 1 clinical trials,
Reverse translational ("bedside to bench") research.
TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.
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