Modifying effects of PM_2.5 and O₃ on heat-related cardiorespiratory hospitalizations in Brazil.

IF 3.9 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Scientific Reports Pub Date : 2025-10-10 DOI:10.1038/s41598-025-19542-1

Weeberb J Requia, Heresh Amini, Paulo Hilario Nascimento Saldiva

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Abstract

Extreme heat is a critical public health threat, particularly in low- and middle-income countries. While its direct health impacts are well documented, less is known about how air pollution modifies heat-related risks. We analyzed daily hospital admissions for circulatory and respiratory diseases in Brazil (2008-2018), combined with high-resolution temperature and pollution (PM₂.₅ and O₃) data. Using generalized additive models and random-effects meta-analysis, we found that PM₂.₅ consistently amplified the effect of heat on respiratory admissions, with a 20.1% increase in risk under high PM₂.₅ conditions (95% CI 4.8-35.4%). In contrast, O₃ showed heterogeneous effects, including a national-level protective association at high concentrations (- 7.6%, 95% CI - 9.6 to - 5.6%). Regional analyses revealed stronger interactions in the North and Southeast. These findings indicate that PM₂.₅ exacerbates, and O₃ variably modifies, heat-related hospitalizations in Brazil, underscoring the need for regionally tailored adaptation and air quality policies.

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PM2.5和O3对巴西热相关心肺住院的调节作用

极端高温是一个严重的公共卫生威胁，特别是在低收入和中等收入国家。虽然空气污染对健康的直接影响有据可查，但人们对空气污染如何改变与热有关的风险知之甚少。我们分析了巴西（2008-2018年）每日循环系统和呼吸系统疾病的住院情况，并结合高分辨率温度和污染（PM₂）。₅和O₃)数据。采用广义加性模型和随机效应元分析，我们发现PM₂。₅持续放大热量对呼吸入口的影响，在高PM 2下风险增加20.1%。₅条件（95% CI 4.8-35.4%）。相比之下，O₃显示出异质效应，包括高浓度的国家级保护性关联（- 7.6%,95% CI - 9.6至- 5.6%）。区域分析显示，北部和东南部的相互作用更强。这些发现表明PM₂。在巴西，₅加剧了与热有关的住院情况，O₃可变地改变了这种情况，这强调了有必要制定适合区域的适应和空气质量政策。

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来源期刊

Scientific Reports Natural Science Disciplines-

CiteScore

7.50

自引率

4.30%

发文量

19567

审稿时长

3.9 months

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