Factors affecting health-related quality of life following axillary lymph node dissection among breast cancer survivors in Egypt.

IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Horeya Mohamed Ismail, Mostafa Ahmed Arafa, Mohamed Mostafa Tahoun, Ahmed Nabil Shama, Amr Abdel Aziz Elsaid
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Abstract

Axillary lymph node dissection (ALND) remains a standard component in the management of breast cancer; however, it may have lasting impacts on patients' health-related quality of life (HRQOL). This study aimed to assess HRQOL and identify its demographic and clinical correlates among breast cancer survivors who underwent ALND. This cross-sectional study was conducted among breast cancer survivors post-ALND at a tertiary oncology center in Alexandria, Egypt. HRQOL was measured using the Arabic FACT-B (version 4.0), and the associated factors were analyzed using multivariate analysis of variance (MANOVA). A total of 150 breast cancer survivors completed the FACT-B questionnaire, with a mean HRQOL score of 88.92 ± 18.01. Of the participants, 18.7% had poor, 64.0% had moderate, and 17.3% had good HRQOL. MANOVA showed that the type of surgery, BMI, HER2 status, lymph node involvement, and tumor stage were significantly associated with HRQOL (p < 0.05). Between-subject analyses and post hoc comparisons confirmed significant group differences across the FACT-B subscales. Overweight or obese participants had poorer Physical, Emotional, and Functional Well-Being. Mastectomy, HER2-positive status, and Stage III disease were associated with lower HRQOL across multiple domains, while lymph node involvement impacted the Physical Well-Being subscale only. Integrating routine HRQOL assessment into survivorship care is essential for identifying individuals at a higher risk of poor outcomes. Tailored follow-up strategies and supportive interventions for these subgroups can enhance the long-term well-being and improve the overall post-treatment quality of life of breast cancer survivors.

影响埃及乳腺癌幸存者腋窝淋巴结清扫后健康相关生活质量的因素
腋窝淋巴结清扫术(ALND)仍然是乳腺癌治疗的标准组成部分;然而,它可能对患者的健康相关生活质量(HRQOL)产生持久的影响。本研究旨在评估接受ALND的乳腺癌幸存者的HRQOL,并确定其人口学和临床相关性。这项横断面研究是在埃及亚历山大的一家三级肿瘤中心进行的,研究对象是alnd后的乳腺癌幸存者。HRQOL采用阿拉伯语FACT-B(4.0版)进行测量,相关因素采用多变量方差分析(MANOVA)进行分析。共有150名乳腺癌幸存者完成了FACT-B问卷,HRQOL平均得分为88.92±18.01。其中,18.7%为差,64.0%为中,17.3%为好。方差分析显示,手术类型、BMI、HER2状态、淋巴结累及和肿瘤分期与HRQOL显著相关
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来源期刊
Scientific Reports
Scientific Reports Natural Science Disciplines-
CiteScore
7.50
自引率
4.30%
发文量
19567
审稿时长
3.9 months
期刊介绍: We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.
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