Archetypal Analysis Reveals Consistent Visual Field Patterns for Stimulus Size III and Size Modulation Perimetry in Glaucoma.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Translational Vision Science & Technology Pub Date : 2025-10-01 DOI:10.1167/tvst.14.10.12

David Szanto, Edward Linton, Michael Wall

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引用次数: 0

Abstract

Purpose: Optic nerve disorders produce identifiable visual field (VF) patterns. Size modulation perimetry (SMP) unlike standard automated perimetry (SAP) shows little degradation of retest variability with increasing VF damage. We hypothesize that VF testing with stimulus size III (size III) and SMP would reveal analogous patterns, supporting interchangeability in clinical practice.

Methods: We analyzed 274 same-day pairs of VFs from 83 eyes of patients with glaucoma. Participants underwent testing every 6 months using size III and SMP VFs. We converted raw sensitivity data to total deviation (TD) scores relative to normative datasets, censoring size III sensitivities below 20 decibels (dB). Archetypal analysis (AA) was applied separately to each modality to identify characteristic VF patterns, or archetypes (ATs). We evaluated both absolute VF patterns and longitudinal VF changes by subtracting baseline measurements. Cosine similarity measured the overlap between ATs in size III and SMP.

Results: Absolute size III and SMP VFs exhibited overlapping patterns, with 95% of ATs demonstrating a cosine similarity of ≥0.50. Change ATs showed lower similarity scores (30% with cosine similarity ≥0.50). However, some ATs still revealed similar underlying defects.

Conclusions: AA consistently extracted comparable VF defect patterns from size III and SMP in glaucoma. Absolute size III patterns closely aligned with SMP, whereas patterns of change showed partial agreement.

Translational relevance: These findings suggest that SAP and SMP capture similar patterns of VF loss.

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原型分析揭示青光眼患者刺激尺寸III和尺寸调制的视野模式一致。

目的：视神经障碍产生可识别的视野（VF）模式。尺寸调制视距法（SMP）与标准自动视距法（SAP）不同，随着VF损伤的增加，重测变异性几乎没有下降。我们假设刺激尺寸III（尺寸III）和SMP的VF测试将揭示类似的模式，支持临床实践中的互换性。方法：对83例青光眼患者的274对同日VFs进行分析。参与者每6个月使用尺寸III和SMP VFs进行测试。我们将原始灵敏度数据转换为相对于规范数据集的总偏差（TD）评分，剔除20分贝（dB）以下的III级灵敏度。原型分析（AA）分别应用于每个模态，以确定特征VF模式或原型（ATs）。我们通过减去基线测量来评估绝对VF模式和纵向VF变化。余弦相似度测量大小为III和SMP的at之间的重叠。结果：绝对尺寸III和SMP VFs呈现重叠模式，95%的ATs显示余弦相似度≥0.50。改变ATs的相似度评分较低（30%，余弦相似度≥0.50）。然而，一些ATs仍然显示出类似的潜在缺陷。结论：AA从III型青光眼和SMP型青光眼中一致提取出相似的VF缺陷模式。绝对尺寸III模式与SMP密切一致，而变化模式显示部分一致。翻译相关性：这些发现表明SAP和SMP捕获了相似的VF丧失模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Vision Science & Technology Engineering-Biomedical Engineering

CiteScore

5.70

自引率

3.30%

发文量

346

审稿时长

25 weeks

期刊介绍： Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO. The journal covers a broad spectrum of work, including but not limited to: Applications of stem cell technology for regenerative medicine, Development of new animal models of human diseases, Tissue bioengineering, Chemical engineering to improve virus-based gene delivery, Nanotechnology for drug delivery, Design and synthesis of artificial extracellular matrices, Development of a true microsurgical operating environment, Refining data analysis algorithms to improve in vivo imaging technology, Results of Phase 1 clinical trials, Reverse translational ("bedside to bench") research. TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.