Disrupting vector competence: exploring radiofrequency exposure as a novel approach to mosquito-borne disease prevention in a changing climate.

Abstract

The global expansion of mosquito-borne diseases such as dengue, chikungunya, Zika, and West Nile virus is a major public health concern, intensified by climate change and environmental alterations. Aedes aegypti, Aedes albopictus, and Culex pipiens are among the most important vectors for these pathogens, contributing to their transmission across increasingly broad geographic areas. In Europe, the expanding distribution and vectorial competence of Ae. albopictus and Cx. pipiens highlight the need for innovative control strategies beyond traditional chemical and mechanical interventions, which face growing limitations due to resistance and sustainability concerns. This review examines the potential of radiofrequency (RF) exposure as a novel method to disrupt mosquito development and reduce vector competence. While the biological effects of RF have been studied in other systems, its impact on mosquito physiology and pathogen transmission remains underexplored. Preliminary findings suggest that RF exposure may alter larval viability, adult emergence, and reproductive capacity, with possible downstream effects on pathogen replication and transmission. We contextualize RF-based approaches alongside other emerging biocontrol strategies, including Wolbachia-based methods, genetic modification, and sterile insect techniques, emphasizing their integration into climate-responsive vector control programs. Additional consideration is given to other arthropod vectors of medical relevance, such as sandflies (Phlebotominae) and biting midges (Culicoides spp.), which contribute to the spread of arboviruses. Finally, we identify research gaps and propose directions for interdisciplinary studies to evaluate the feasibility, efficacy, and ecological impact of RF-based interventions. By targeting mosquito competence through non-chemical, scalable technologies, RF exposure offers a promising avenue to strengthen arbovirus prevention in the context of climate-driven vector expansion.