[Hypotensive activity of dinitrosyl complexes of iron and proteins in anesthetized animals].

Abstract

It had been shown before that dinitrosyl iron complexes (DNIC) administration led to long-lasting decrease in animal arterial pressure. It was suggested that this effect depended on protein DNIC formation which were an NO-store in animal tissues. NO was hypotensive agent. To test this suggestion low molecular weight DNIC with thiosulphate or phosphate were incubated with blood plasma of dogs and rats which evoked protein DNIC formation proved by EPR method. Injections of these plasma samples into narcotized dogs and rats produced hypotensive responses similar to those produced by low molecular weight DNIC. These complexes, measured by EPR method, were formed as a result of Fe(NO)2-groups transfer from low molecular weight DNIC to protein RS-groups.