Predictive Factors for Failed Sentinel Lymph Node Mapping in Endometrial Cancer: A Retrospective Multicenter Study.

IF 1.9 3区医学 Q3 ONCOLOGY

Journal of Surgical Oncology Pub Date : 2025-10-11 DOI:10.1002/jso.70106

Cristina Taliento, Gennaro Scutiero, Giuseppe Cucinella, Vito Chiantera, Giovanni Pontrelli, Marko Klaric, Dragan Belci, Martin Steinkasserer, Stefano Restaino, Ruby Martinello, Orsola Brasile, Martina Arcieri, Sara Pregnolato, Giulia Pellecchia, Giulia Soraci, Rosa Taratufolo, Carmelia Milano, Marcello Desgro, Francesca Davià, Mariano Catello Di Donna, Dino Becic, Sara Notaro, Giuseppe Vizzielli, Pantaleo Greco

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引用次数: 0

Abstract

Background and objectives: This study aims to evaluate the predictive factors associated with failed sentinel lymph node (SLN) mapping in a large, retrospective cohort of patients with early-stage endometrial cancer (EC).

Methods: We retrospectively evaluated a series of EC patients who underwent laparoscopic SLN mapping with intracervical indocyanine green (ICG) injection in five referred oncological centers from January 2019 to March 2024. We compared the clinical and pathological features of bilateral and failed SLN mapping, which was defined as either unilateral mapping or no SLN mapping. Logistic regression was used to identify predictors of failure.

Results: Among 623 analyzed patients, 437 (70.14%) had a successful bilateral procedure. On univariate analysis, age (p = 0.03), non-endometrioid histology (p = 0.02) and previous vaginal delivery (p = 0.015) were significant associated with failed SLN mapping. On multivariable analysis, only increasing age (OR 1.03; 95% CI, 1.01-1.04, p = 0.03) and non-endometrioid histology (OR 1.81; 95% CI, 1.01-3.19) were independently associated with unsuccessful procedure. No significant differences were observed for BMI, enlarged lymph nodes, intraoperative lysis of adhesion, LVSI, grade 3, and FIGO stage.

Conclusions: Increasing age and non-endometrioid histology are independent predictors of bilateral SLN mapping failure in EC patients undergoing SLN mapping with cervical ICG injection.

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子宫内膜癌前哨淋巴结定位失败的预测因素：一项回顾性多中心研究。

背景和目的：本研究旨在评估与早期子宫内膜癌（EC）患者前哨淋巴结（SLN）定位失败相关的预测因素。方法：我们回顾性评估了2019年1月至2024年3月在五个转诊肿瘤中心接受腹腔镜宫颈内注射吲哚青绿（ICG） SLN定位的一系列EC患者。我们比较了双侧和SLN标测失败的临床和病理特征，定义为单侧SLN标测或无SLN标测。使用逻辑回归来确定失败的预测因素。结果：623例患者中，437例（70.14%）双侧手术成功。单因素分析显示，年龄（p = 0.03）、非子宫内膜样组织学（p = 0.02）和阴道分娩史（p = 0.015）与SLN定位失败有显著相关性。在多变量分析中，只有年龄增加（OR 1.03; 95% CI, 1.01-1.04, p = 0.03）和非子宫内膜样组织学（OR 1.81; 95% CI, 1.01-3.19）与手术失败独立相关。BMI、淋巴结肿大、术中粘连溶解、LVSI、3级和FIGO分期均无显著差异。结论：年龄增长和非子宫内膜样组织学是宫颈ICG注射SLN定位的EC患者双侧SLN定位失败的独立预测因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Surgical Oncology 医学-外科

CiteScore

4.70

自引率

4.00%

发文量

367

审稿时长

2 months

期刊介绍： The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.