Associations of PEDF Genetic Polymorphisms with Retinopathy of Prematurity.

IF 2.7 2区 医学 Q1 OPHTHALMOLOGY
Pei-Liang Wu, Eugene Yu-Chuan Kang, Xiao Chun Ling, Chia-Wen Lee, Kuan-Jen Chen, Nan-Kai Wang, Laura Liu, Yih-Shiou Hwang, Chi-Chun Lai, Shun-Fa Yang, Wei-Chi Wu
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Abstract

The current study explores the association between pigment epithelium-derived factor (PEDF) polymorphisms and risk, severity, susceptibility, and treatment response of retinopathy of prematurity (ROP). The study is designed in a prospective cohort manner, where all participating patients were recruited from two hospital branches. Three single nucleotide polymorphisms of PEDF with the highest allele frequency were selected. The genomic data were extracted from the patient's blood and amplified using polymerase chain reaction (PCR). A multivariate logistic regression model assessed the association between PEDF polymorphisms and ROP risk. Risk evaluation for each polymorphism was performed using an adjusted odds ratio (OR). 51% of the 585 recruited patients developed ROP, subdivided into groups of type-2 or milder ROP and type-1 ROP. The results showed that patients with polymorphic genotype GA and the combination of genotypes GA and AA in the polymorphism of rs11658342 were associated with a higher risk of developing both type-2 or milder ROP (aOR = 1.757, p = 0.037; OR = 1.370, p = 0.013) and type-1 ROP (OR = 1.950, p = 0.013; OR = 1.358, p = 0.017). Patients with the polymorphic AA genotype in the polymorphism of rs12603825 had a higher risk of type-1 ROP (OR = 2.740, p = 0.029). The results indicate that patients with GA and AA genotypes in rs11658342 and rs12603825 of the PEDF polymorphism may serve as prognostic factors for ROP risks and severity.

PEDF基因多态性与早产儿视网膜病变的关系。
本研究探讨色素上皮衍生因子(PEDF)多态性与早产儿视网膜病变(ROP)的风险、严重程度、易感性和治疗反应之间的关系。该研究采用前瞻性队列方式设计,所有参与研究的患者均来自两家医院分支机构。筛选出3个等位基因频率最高的PEDF单核苷酸多态性。从患者血液中提取基因组数据,并使用聚合酶链反应(PCR)进行扩增。多变量逻辑回归模型评估PEDF多态性与ROP风险之间的关系。使用调整后的优势比(OR)对每个多态性进行风险评估。585名入选患者中有51%发生ROP,分为2型或轻度ROP组和1型ROP组。结果显示,rs11658342基因多态性GA基因型及GA基因型与AA基因型合并的患者发生2型或轻度ROP (aOR = 1.757, p = 0.037; or = 1.370, p = 0.013)和1型ROP (or = 1.950, p = 0.013; or = 1.358, p = 0.017)的风险均较高。rs12603825多态性AA基因型的患者发生1型ROP的风险较高(OR = 2.740, p = 0.029)。结果提示,PEDF多态性rs11658342和rs12603825基因型为GA和AA型的患者可能是影响ROP风险和严重程度的预后因素。
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来源期刊
Experimental eye research
Experimental eye research 医学-眼科学
CiteScore
6.80
自引率
5.90%
发文量
323
审稿时长
66 days
期刊介绍: The primary goal of Experimental Eye Research is to publish original research papers on all aspects of experimental biology of the eye and ocular tissues that seek to define the mechanisms of normal function and/or disease. Studies of ocular tissues that encompass the disciplines of cell biology, developmental biology, genetics, molecular biology, physiology, biochemistry, biophysics, immunology or microbiology are most welcomed. Manuscripts that are purely clinical or in a surgical area of ophthalmology are not appropriate for submission to Experimental Eye Research and if received will be returned without review.
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