PROGRESS IN T-CELL IMMUNE RESEARCH ON HYPERLIPIDEMIC PANCREATITIS.

Abstract

T cells play a significant role in the immune response of hyperlipidemic pancreatitis, with their function affected by dysregulated lipid metabolism. In acute pancreatitis, rapid T-cell activation and Th2 differentiation correlate with disease severity, involving CD4+ T cells in inflammation and IL-6 in systemic T-cell activation. Chronic pancreatitis features regulatory T-cell responses and increased central memory T cells. Hyperlipidemia exacerbates pancreatic inflammation via mechanisms like ferroptosis and fatty acid-induced acinar cell pyroptosis. T-cell-targeted immunotherapies show promise, though challenges remain. Other immune cells (e.g., macrophages), environmental factors, and calcium signaling also influence the disease.