Evolving Indications of Esophageal Peroral Endoscopic Myotomy (E-POEM): A Review of Expanding Applications in Esophageal Pathologies.

Q1 Medicine

Current Gastroenterology Reports Pub Date : 2025-10-10 DOI:10.1007/s11894-025-01016-z

Yervant Ichkhanian, John M DeWitt

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引用次数: 0

Abstract

Purpose of review: Since its introduction in 2010, peroral endoscopic myotomy (POEM) has reshaped the management of esophageal motility disorders. Originally designed for achalasia, it has expanded into a versatile therapeutic option for a range of esophageal conditions. This review summarizes current evidence on the role of esophageal POEM (E-POEM) across diverse pathologies.

Recent findings: Emerging data suggest favorable outcomes of E-POEM for non-achalasia disorders, including spastic esophageal disorders, esophagogastric junction outflow obstruction (EGJOO), diverticular disease, revisional therapy, and other rare indications. However, the evidence remains limited, and careful patient selection is essential before offering treatment. E-POEM has progressed from a procedure for classical achalasia to a promising approach for complex and refractory esophageal conditions. Its broader application may be beneficial when performed in appropriately selected patients under expert hands.

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食管经口内窥镜肌切开术适应症的演变：食管病理扩展应用综述。

回顾目的：自2010年引入以来，经口内窥镜肌切开术（POEM）重塑了食管运动障碍的治疗。最初是为贲门失弛缓症设计的，现已扩展为多种食道疾病的多功能治疗选择。本文综述了食道POEM （E-POEM）在不同病理中的作用。最新发现：新数据显示，E-POEM治疗非贲门失弛缓症疾病的良好结果，包括痉挛性食管疾病、食管胃交界流出梗阻（EGJOO）、憩室疾病、修正治疗和其他罕见适应症。然而，证据仍然有限，在提供治疗之前，仔细选择患者是必不可少的。E-POEM已经从一种治疗经典贲门失弛缓症的方法发展成为一种治疗复杂难治性食管疾病的有前途的方法。在专家的指导下，在适当选择的患者中进行更广泛的应用可能是有益的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Gastroenterology Reports Medicine-Gastroenterology

CiteScore

7.80

自引率

0.00%

发文量

期刊介绍： As the field of gastroenterology and hepatology rapidly evolves, the wealth of published literature can be overwhelming. The aim of the journal is to help readers stay abreast of such advances by offering authoritative, systematic reviews by leading experts. We accomplish this aim by appointing Section Editors who invite international experts to contribute review articles that highlight recent developments and important papers published in the past year. Major topics in gastroenterology are covered, including pediatric gastroenterology, neuromuscular disorders, infections, nutrition, and inflammatory bowel disease. These reviews provide clear, insightful summaries of expert perspectives relevant to clinical practice. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.