Self-healing β-cyclodextrin/hyaluronic acid hydrogel with enhanced strength and self-healing efficiency.

IF 8.5 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Biological Macromolecules Pub Date : 2025-10-08 DOI:10.1016/j.ijbiomac.2025.148177

Ruina Chen, Yaxin Hu, Siying Zhang, Chunchun Shi, Zefeng Li, Zikui Bai, Yingshan Zhou

{"title":"Self-healing β-cyclodextrin/hyaluronic acid hydrogel with enhanced strength and self-healing efficiency.","authors":"Ruina Chen, Yaxin Hu, Siying Zhang, Chunchun Shi, Zefeng Li, Zikui Bai, Yingshan Zhou","doi":"10.1016/j.ijbiomac.2025.148177","DOIUrl":null,"url":null,"abstract":"<p><p>Hyaluronic acid (HA) self-healing hydrogels commonly suffer from an imbalance between mechanical properties and self-healing efficiency. To address this issue, we introduce carboxymethyl-β-cyclodextrin (β-CD) into the HA hydrogel system, which provides multiple crosslinking sites via β-CD's cyclic structure to improve its self-healing capability. The β-cyclodextrin/hyaluronic acid (ACD) hydrogels were prepared through dynamic acylhydrazone bond formation between aldehyde-modified HA (AHA) and hydrazide-modified carboxymethyl-β-cyclodextrin (β-CDD). Compared to aldehyde-modified HA/3,3'-dithiobis (propionyl hydrazide) (AHA/DTP, AD) hydrogels (~0.17 MPa), ACD hydrogels exhibited enhanced compressive strength of ~0.29 MPa, which was attributed to multiple interactions, such as dynamic covalent acylhydrazone bonds, hydrogen bonds, and physical filling. Furthermore, ACD hydrogels achieved 100 % healing efficiency in Young's modulus within 10 min, significantly higher than AD hydrogel (80 %) due to synergistic effects of dynamic covalent bonds, including acylhydrazone and disulfide bonds and hydrogen bonds. This hydrogel holds potential for various biomedical applications.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"148177"},"PeriodicalIF":8.5000,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Biological Macromolecules","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1016/j.ijbiomac.2025.148177","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Hyaluronic acid (HA) self-healing hydrogels commonly suffer from an imbalance between mechanical properties and self-healing efficiency. To address this issue, we introduce carboxymethyl-β-cyclodextrin (β-CD) into the HA hydrogel system, which provides multiple crosslinking sites via β-CD's cyclic structure to improve its self-healing capability. The β-cyclodextrin/hyaluronic acid (ACD) hydrogels were prepared through dynamic acylhydrazone bond formation between aldehyde-modified HA (AHA) and hydrazide-modified carboxymethyl-β-cyclodextrin (β-CDD). Compared to aldehyde-modified HA/3,3'-dithiobis (propionyl hydrazide) (AHA/DTP, AD) hydrogels (~0.17 MPa), ACD hydrogels exhibited enhanced compressive strength of ~0.29 MPa, which was attributed to multiple interactions, such as dynamic covalent acylhydrazone bonds, hydrogen bonds, and physical filling. Furthermore, ACD hydrogels achieved 100 % healing efficiency in Young's modulus within 10 min, significantly higher than AD hydrogel (80 %) due to synergistic effects of dynamic covalent bonds, including acylhydrazone and disulfide bonds and hydrogen bonds. This hydrogel holds potential for various biomedical applications.

查看原文本刊更多论文

自修复β-环糊精/透明质酸水凝胶，增强强度和自修复效率。

透明质酸（HA）自愈水凝胶通常存在力学性能与自愈效率不平衡的问题。为了解决这一问题，我们将羧甲基-β-环糊精（β-CD）引入到HA水凝胶体系中，通过β-CD的环结构提供多个交联位点，提高其自愈能力。通过醛修饰的透明质酸（AHA）和酰胺修饰的羧甲基β-环糊精（β-CDD）之间动态形成酰基腙键，制备了β-环糊精/透明质酸（ACD）水凝胶。与醛改性HA/3,3′-丙酰肼（AHA/DTP， AD）水凝胶（~0.17 MPa）相比，ACD水凝胶的抗压强度提高了~0.29 MPa，这是由于动态共价酰基腙键、氢键和物理填充等多种相互作用所致。此外，由于动态共价键（包括酰基腙键、二硫键和氢键）的协同作用，ACD水凝胶在10 min内的杨氏模量愈合效率达到了100% %，显著高于AD水凝胶（80% %）。这种水凝胶具有多种生物医学应用的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Biological Macromolecules 生物-生化与分子生物学

CiteScore

13.70

自引率

9.80%

发文量

2728

审稿时长

64 days

期刊介绍： The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.