Which ‘dose rate’ definition describes the FLASH sparing effect for scanned proton beams? A meta-analysis of skin murine data

IF 5.3 1区医学 Q1 ONCOLOGY

Radiotherapy and Oncology Pub Date : 2025-10-10 DOI:10.1016/j.radonc.2025.111206

Isabella Colizzi , Per Rugaard Poulsen , Brita Sørensen , David Meer , Antony John Lomax , Serena Psoroulas

引用次数: 0

Abstract

We compiled preclinical proton PBS skin toxicity data to assess how various dose rate definitions (field, average, and dose average) explain the FLASH sparing effect. Only average dose rate (ADR), accounting for ‘effective irradiation time,’ reliably describes it. We identified high-dose and ADR regions where the effect was consistently observed.

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哪个“剂量率”定义描述了扫描质子束的FLASH保留效应？皮肤鼠数据的荟萃分析

我们汇编了临床前质子PBS皮肤毒性数据，以评估不同剂量率定义（场、平均和平均剂量）如何解释FLASH保护效应。只有平均剂量率（ADR），即“有效辐照时间”，才能可靠地描述它。我们确定了高剂量和不良反应区域，这些区域的效果一直被观察到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiotherapy and Oncology 医学-核医学

CiteScore

10.30

自引率

10.50%

发文量

2445

审稿时长

45 days

期刊介绍： Radiotherapy and Oncology publishes papers describing original research as well as review articles. It covers areas of interest relating to radiation oncology. This includes: clinical radiotherapy, combined modality treatment, translational studies, epidemiological outcomes, imaging, dosimetry, and radiation therapy planning, experimental work in radiobiology, chemobiology, hyperthermia and tumour biology, as well as data science in radiation oncology and physics aspects relevant to oncology.Papers on more general aspects of interest to the radiation oncologist including chemotherapy, surgery and immunology are also published.