Case-based surveillance of bacterial meningitis following MenAfrivac™ introduction at Sourô Sanou University Hospital, Bobo-Dioulasso, Burkina Faso, 2011-2021

IF 1.7 Q4 INFECTIOUS DISEASES

IJID regions Pub Date : 2025-09-15 DOI:10.1016/j.ijregi.2025.100764

Zoungrana Jacques , Kabore D. Odilon , Tonde Issa , Ouattara Cheick Ahmed , Kiodima M.S. Odette , Muhigwa Merci , Diallo Ismael , Sawadogo Yacouba , Poda Armel , Ouedraogo Abdoul-Salam

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引用次数: 0

Abstract

Objectives

To describe the distribution of Neisseria meningitidis serogroups in bacterial meningitis cases diagnosed by polymerase chain reaction at the Sourô Sanou University Hospital, Bobo-Dioulasso, from 2011 to 2021.

Methods

A descriptive cross-sectional study was conducted using retrospective data from cerebrospinal fluid samples collected in Bobo-Dioulasso and surrounding districts and analyzed at the National Reference Laboratory for bacterial meningitis.

Results

Among 3823 suspected cases, 3341 samples underwent polymerase chain reaction, confirming 1186 cases (35.5%). The highest number of samples was recorded in 2012 (32.9%), mainly from Dafra district (20.2%). Streptococcus pneumoniae was the leading pathogen (51.9%), followed by N. meningitidis (46.1%) and Haemophilus influenzae type b (1.9%). Most N. meningitidis cases (69.5%) occurred in 2012, declining thereafter, with no cases by 2021. Serogroup W predominated (69.7%), while serogroups A and B were absent.

Conclusions

The results emphasize the need to strengthen epidemiological surveillance and adapt vaccination strategies to achieve meningitis elimination in Africa.

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2011-2021年在布基纳法索博博-迪乌拉索Sourô萨努大学医院引入MenAfrivac™后基于病例的细菌性脑膜炎监测

目的了解2011 - 2021年博博-迪乌拉索Sourô萨努大学医院聚合酶链反应诊断的细菌性脑膜炎病例中脑膜炎奈瑟菌的血清群分布。方法对在Bobo-Dioulasso及周边地区收集的脑脊液样本进行回顾性分析，并在细菌性脑膜炎国家参考实验室进行分析，进行描述性横断面研究。结果3823例疑似病例中，聚合酶链反应3341例，确诊1186例（占35.5%）。2012年记录的样本数量最多（32.9%），主要来自Dafra区（20.2%）。肺炎链球菌是主要病原菌（51.9%），其次是脑膜炎奈瑟菌（46.1%）和b型流感嗜血杆菌（1.9%）。大多数脑膜炎奈瑟菌病例（69.5%）发生在2012年，此后下降，到2021年无病例。以W血清组为主（69.7%），A、B血清组缺失。结论本研究结果强调了加强流行病学监测和调整疫苗接种策略以实现非洲消除脑膜炎的必要性。

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