The hidden toll: Atrophy of key central nervous system relays in African American women with multiple sclerosis

IF 2.5 4区医学 Q3 IMMUNOLOGY

Journal of neuroimmunology Pub Date : 2025-10-06 DOI:10.1016/j.jneuroim.2025.578776

Nabeela Nathoo , Nur Neyal , Jiye Son , Christopher G. Schwarz , Elizabeth J. Atkinson , Holly A. Morrison , June Kendall Thomas , John D. Port , Kejal Kantarci , Orhun H. Kantarci , Burcu Zeydan

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引用次数: 0

Abstract

Background

African American persons with MS (AApwMS) have more aggressive clinical and imaging outcomes than White American pwMS (WApwMS), including lower brain and spinal cord (SC) volumes. However, imaging studies are lacking considering the effects of sex, race, and ethnicity together.

Objective

Compare MS clinical and imaging features among AApwMS and WApwMS, incorporating the modifying effects of sex, race, and ethnicity.

Methods

Clinical variables and MRI were obtained for AApwMS and WApwMS.

Results

Thirty-five MRIs in 28 AApwMS (61 % female) and 255 MRIs in 91 WApwMS (68 % female) were evaluated. AApwMS had a shorter MS disease duration (median 5.9 years, IQR 2.7–13.1) compared to WApwMS (9.4 years, IQR 3.8–17.0; p = 0.034). Fewer AApwMS ever used disease modifying therapy (69 %) compared to WApwMS (92 %; p < 0.001), while the likelihood of having progressive MS and developing severe disability were similar between groups (p > 0.05). AA women with MS had smaller thalamus (p = 0.016), cerebellar grey matter (p = 0.025), and SC-C2 (p = 0.005) volumes than WA women with MS. Although multiple brain and SC regions were smaller in AA men than WA men with MS, the differences were not significant.

Conclusion

Interaction between sex, race, and ethnicity may influence differences in imaging metrics of key central nervous system relays, likely preceding clinical worsening in MS.

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隐藏的代价：患有多发性硬化症的非裔美国妇女的关键中枢神经系统中继萎缩

非裔美国人多发性硬化症（AApwMS）的临床和影像学结果比美国白人多发性硬化症（WApwMS）更积极，包括脑和脊髓（SC）体积更小。然而，影像学研究缺乏综合考虑性别、种族和民族的影响。目的比较AApwMS和WApwMS的临床和影像学特征，并结合性别、种族和民族的改变作用。方法获取AApwMS和WApwMS的临床指标和MRI数据。结果28例AApwMS（女性占61%）共35个mri， 91例WApwMS（女性占68%）共255个mri。与WApwMS（9.4年，IQR 3.8-17.0, p = 0.034）相比，AApwMS的MS病程较短（中位5.9年，IQR 2.7-13.1）。与WApwMS （92%; p < 0.001）相比，AApwMS使用过疾病改善治疗的患者较少（69%），而两组之间发生进展性MS和发生严重残疾的可能性相似（p < 0.05）。AA女性MS的丘脑（p = 0.016）、小脑灰质（p = 0.025）和SC- c2 （p = 0.005）体积均小于WA女性MS。AA男性MS的多脑区和SC区均小于WA男性MS，但差异不显著。结论性别、种族和民族之间的相互作用可能影响关键中枢神经系统转导成像指标的差异，可能在MS临床恶化之前发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of neuroimmunology 医学-免疫学

CiteScore

6.10

自引率

3.00%

发文量

154

审稿时长

37 days

期刊介绍： The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.