Development and application of recombinant collagen in dermatology

IF 5.1 3区工程技术 Q1 CHEMISTRY, APPLIED

Reactive & Functional Polymers Pub Date : 2025-10-02 DOI:10.1016/j.reactfunctpolym.2025.106495

Le Li , Wan Liu , Xiaofei Xie , Huan Lei

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引用次数: 0

Abstract

Various skin diseases have become increasingly common in people's daily lives due to adverse environmental factors, unhealthy lifestyle habits, and the influence of diseases, such as dermatitis, acne, scars, skin photoaging, and various skin injuries, which have a serious impact on people's physical and mental health. Recombinant collagen is a recombinant protein synthesized by transferring human collagen gene into expression host, such as plant, animal or microorganism, and successfully expressing it. Compared with traditional animal derived collagen, it has advantages such as good moisturizing properties, low immunogenicity, biocompatibility, anti-inflammatory properties, antioxidant properties, promotion of cell proliferation and collagen expression, and has shown broad application prospects in the field of dermatology. However, there are several inadequacies in the current technology that limit the application of recombinant collagen in dermatology: (1) whether the purity and impurities of recombinant collagen meet medical standards; (2) further research is needed on the effectiveness and safety of recombinant collagen in medicine. Therefore, we reviewed the preparation, basic properties, applications, and prospects of recombinant collagen in the field of dermatology, providing insights for its wider application in dermatology and clinical treatment.

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重组胶原蛋白在皮肤病学中的发展与应用

由于不良的环境因素、不健康的生活习惯以及疾病的影响，各种皮肤病在人们的日常生活中越来越普遍，如皮炎、痤疮、疤痕、皮肤光老化、各种皮肤损伤等，严重影响着人们的身心健康。重组胶原蛋白是将人胶原蛋白基因转入植物、动物或微生物等表达宿主并成功表达而合成的重组蛋白。与传统动物源性胶原蛋白相比，具有良好的保湿性能、低免疫原性、生物相容性、抗炎性能、抗氧化性能、促进细胞增殖和胶原蛋白表达等优点，在皮肤医学领域显示出广阔的应用前景。然而，目前的技术还存在几方面的不足，限制了重组胶原蛋白在皮肤科的应用：(1)重组胶原蛋白的纯度和杂质是否达到医学标准；(2)重组胶原蛋白在医学上的有效性和安全性有待进一步研究。因此，本文综述了重组胶原蛋白的制备、基本性质、应用及其在皮肤病学领域的前景，为其在皮肤病学和临床治疗中的更广泛应用提供参考。

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来源期刊

Reactive & Functional Polymers 工程技术-高分子科学

CiteScore

8.90

自引率

5.90%

发文量

259

审稿时长

27 days

期刊介绍： Reactive & Functional Polymers provides a forum to disseminate original ideas, concepts and developments in the science and technology of polymers with functional groups, which impart specific chemical reactivity or physical, chemical, structural, biological, and pharmacological functionality. The scope covers organic polymers, acting for instance as reagents, catalysts, templates, ion-exchangers, selective sorbents, chelating or antimicrobial agents, drug carriers, sensors, membranes, and hydrogels. This also includes reactive cross-linkable prepolymers and high-performance thermosetting polymers, natural or degradable polymers, conducting polymers, and porous polymers. Original research articles must contain thorough molecular and material characterization data on synthesis of the above polymers in combination with their applications. Applications include but are not limited to catalysis, water or effluent treatment, separations and recovery, electronics and information storage, energy conversion, encapsulation, or adhesion.