Evaluation of the frequency of Dectin-1 rs3901533 A > C and rs7309123 G > C gene variants in patients with acute myeloid leukemia (AML): A case-control study

IF 0.9 Q4 GENETICS & HEREDITY

Human Gene Pub Date : 2025-12-01 Epub Date: 2025-09-22 DOI:10.1016/j.humgen.2025.201482

Davood Alinezhad Dezfuli , Ehsan Sarbazjoda , Nasrin Amirrajab , Tina Vosoughi , Alireza Momeni , Mohammad Ali Jalali Far

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Abstract

Background

Acute myeloid leukemia (AML) is a serious blood cancer mainly affecting adults, and its predisposing genetic factors remain unclear. While recent studies have linked dectin-1 polymorphisms to fungal infection risk in AML, their relationship with AML susceptibility has not been studied. This study evaluates the association between two dectin-1 single-nucleotide polymorphisms (SNPs) of rs3901533 A > C and rs7309123 G > C and AML risk.

Methods & materials

A total of 103 participants (53 AML patients and 50 age- and sex-matched healthy controls) from the Iranian population were included in this study. Both of the polymorphisms were genotyped using the tetra-ARMS-PCR method.

Results

The genotype distributions of rs3901533 A > C and rs7309123 G > C polymorphisms did not differ significantly between AML patients and controls under additive, dominant, or recessive genetic models (p-value > 0.05). Furthermore, allele frequencies for both SNPs showed no significant association with AML risk (p-value > 0.05). None of the genotypes or alleles increased the risk of AML (p-value > 0.05).

Conclusions

Neither the rs3901533 A > C nor the rs7309123 G > C polymorphisms are contributors to increased susceptibility to AML. However, further investigations are needed.

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急性髓性白血病（AML）患者Dectin-1 rs3901533 A > C和rs7309123 G > C基因变异频率的评估：一项病例对照研究

急性髓系白血病（acute myeloid leukemia， AML）是一种主要影响成人的严重血癌，其易感遗传因素尚不清楚。虽然最近的研究将dectin-1多态性与AML真菌感染风险联系起来，但它们与AML易感性的关系尚未研究。本研究评估了rs3901533 A >； C和rs7309123 G >； C的两个检测素-1单核苷酸多态性（snp）与AML风险之间的关系。方法材料本研究共纳入103名伊朗人群参与者（53名AML患者和50名年龄和性别匹配的健康对照）。两种多态性均采用4 - arms - pcr方法进行基因分型。结果rs3901533 A >； C和rs7309123 G >； C在加性、显性和隐性遗传模型下的基因型分布在AML患者和对照组之间无显著差异（p值>； 0.05）。此外，两种snp的等位基因频率与AML风险无显著关联（p值>； 0.05）。所有基因型或等位基因均未增加AML的风险（p值>； 0.05）。结论rs3901533 A >； C和rs7309123 G >； C多态性都不是AML易感性增加的因素。然而，还需要进一步的调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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