Fabrication of superhydrophobic coating on medical polycarbonate surface with anti-biofouling performance and biocompatibility

IF 5.4 2区化学 Q2 CHEMISTRY, PHYSICAL

Colloids and Surfaces A: Physicochemical and Engineering Aspects Pub Date : 2025-10-10 DOI:10.1016/j.colsurfa.2025.138621

Xindi Wang , Guangyao Dai , Shunli Gu , Niuniu Qin , Ruiqi Liang , Changhao Wang , Yashao Chen

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引用次数: 0

Abstract

Polycarbonate (PC) materials play an important role in the biomedical field due to their inherent physical properties, which are widely used as medical device packaging and medical connectors. However, long-term contact between PC materials and blood can lead to blood clotting and medical device malfunctions. Moreover, biological pollution always causes life-threatening complications. Inspired by the lotus leaf in nature, we have designed micro/nano structures and a superhydrophobic coating on the surface of PC. Trimethoxysilylpropanethiol (KH590) was firstly employed to construct micro/nano structures on the PC surface to yield PC-KH590. Then, the vinyl terminated polydimethylsiloxane (vinyl PDMS) was grafted onto PC-KH590 surface by a thiol-ene click chemistry reaction, fabricating a superhydrophobic PC materials (PC-KH590-vinyl PDMS) with a water contact angel (WCA) up to 154.7°. The PC-KH590-vinyl PDMS exhibits good mechanical stability even treated by sandpaper friction, water flushing, thermal processing and harsh media. The PC-KH590-vinyl PDMS shows a self-cleaning behavior against varied liquids and blood. Furthermore, the PC-KH590-vinyl PDMS can prevent adhesions of protein and platelet, and exhibit a low hemolysis ratio at 0.15 % and good cell viability. Therefore, the superhydrophobic PC-KH590-vinyl PDMS materials would provide a facile strategy to improve PC properties, making them as potential candidates in biomedical fields.

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医用聚碳酸酯表面具有抗生物污性能和生物相容性的超疏水涂层的制备

聚碳酸酯（PC）材料因其固有的物理特性在生物医学领域发挥着重要作用，被广泛用作医疗器械封装和医疗连接器。然而，PC材料与血液的长期接触可能导致血液凝固和医疗设备故障。此外，生物污染总是会导致危及生命的并发症。受到自然界荷叶的启发，我们在PC表面设计了微纳米结构和超疏水涂层。首先利用三甲氧基硅丙硫醇（KH590）在PC表面构建微纳结构，得到PC-KH590。然后，将乙烯基端部聚二甲基硅氧烷（乙烯基PDMS）通过巯基点击化学反应接枝到PC- kh590表面，制备了水接触角（WCA）高达154.7°的超疏水PC材料（PC- kh590 -乙烯基PDMS）。pc - kh590 -乙烯基PDMS即使经过砂纸摩擦、水冲洗、热加工和恶劣介质处理，也具有良好的机械稳定性。pc - kh590 -乙烯基PDMS对各种液体和血液具有自洁性。此外，pc - kh590 -乙烯基PDMS可以防止蛋白质和血小板的粘附，具有较低的溶血率（0.15 %）和良好的细胞活力。因此，超疏水PC- kh590 -乙烯基PDMS材料将为改善PC性能提供一种简便的策略，使其成为生物医学领域的潜在候选者。

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来源期刊

Colloids and Surfaces A: Physicochemical and Engineering Aspects 化学-物理化学

CiteScore

8.70

自引率

9.60%

发文量

2421

审稿时长

56 days

期刊介绍： Colloids and Surfaces A: Physicochemical and Engineering Aspects is an international journal devoted to the science underlying applications of colloids and interfacial phenomena. The journal aims at publishing high quality research papers featuring new materials or new insights into the role of colloid and interface science in (for example) food, energy, minerals processing, pharmaceuticals or the environment.