Chitosan/acetoacetylated poly(vinyl alcohol) nanofibers incorporating starch-derived carbon quantum dots with pH-responsive color change for wound dressings

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers Pub Date : 2025-09-27 DOI:10.1016/j.carbpol.2025.124477

Ying Yao , Yu-I Hsu , Selina Sonntag , Alicia Fernández-Colino , Stefan Jockenhövel , Hiroshi Uyama

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引用次数: 0

Abstract

Monitoring wound healing status through pH-responsive visual cues is essential for the effective management of chronic wounds. In this study, we developed biomass-derived carbon quantum dots (CQDs) using hydroxypropyl starch as the carbon source via a simple, eco-friendly synthesis strategy. Composite nanofibrous dressings were subsequently fabricated by incorporating CQDs with acetoacetylated polyvinyl alcohol (AAPVA) and chitosan (CS) through electrospinning. The resulting CQDs/CS/AAPVA nanofibers exhibited pronounced optical responsiveness within the pH range of 5–8, displaying visible color and fluorescence changes under visible and ultraviolet light. Furthermore, quantitative pH detection was achieved through RGB image analysis, demonstrating strong practical potential for wound monitoring. Owing to the synergistic effects between CQDs and CS, the composite nanofibers also exhibited excellent mechanical strength (Tensile stress = 10.0 ± 1.2 MPa), high swelling capacity (∼ 619.4 ± 26.8 %), structural stability, and biocompatibility, underscoring their significant promise for intelligent chronic wound management and remote monitoring.

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含有淀粉衍生碳量子点的壳聚糖/乙酰乙酰化聚乙烯醇纳米纤维用于伤口敷料，具有ph响应性颜色变化

通过ph反应性视觉线索监测伤口愈合状态对于有效管理慢性伤口至关重要。在这项研究中，我们通过一种简单、环保的合成策略，开发了以羟丙基淀粉为碳源的生物质衍生碳量子点（CQDs）。将CQDs与乙酰乙酰化聚乙烯醇（AAPVA）和壳聚糖（CS）通过静电纺丝制备复合纳米纤维敷料。所制备的CQDs/CS/AAPVA纳米纤维在pH值为5-8的范围内具有明显的光学响应性，在可见光和紫外光下均表现出可见的颜色和荧光变化。此外，通过RGB图像分析实现了定量pH检测，显示出强大的伤口监测实用潜力。由于CQDs和CS之间的协同作用，复合纳米纤维还具有优异的机械强度（拉伸应力= 10.0±1.2 MPa），高溶胀能力（~ 619.4±26.8%），结构稳定性和生物相容性，强调了它们在智能慢性伤口管理和远程监测方面的重要前景。

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来源期刊

Carbohydrate Polymers 化学-高分子科学

CiteScore

22.40

自引率

8.00%

发文量

1286

审稿时长

47 days

期刊介绍： Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.