Phthalocyanine-nanodiamond conjugating mechanisms and their influence on photodynamic activity

IF 5.1 3区材料科学 Q2 MATERIALS SCIENCE, COATINGS & FILMS

Diamond and Related Materials Pub Date : 2025-10-05 DOI:10.1016/j.diamond.2025.112930

V.R. Gudkova , V. Yu. Dolmatov , E. Yu. Parshina , I.D. Kormschikov , D.A. Gvozdev , E.G. Maksimov

引用次数: 0

Abstract

In this work, we analyzed the non-covalent binding of water-soluble charged metallophthalocyanines to nanodiamonds with variable surface parameters and identified two conjugation mechanisms. The first mechanism is π-π stacking which leads to the phthalocyanine fluorescence quenching, decrease of singlet oxygen quantum yield and photodynamic efficiency against A431 cells. The second mechanism is realized by electrostatic interactions, with preservation of phthalocyanine fluorescent properties and variable singlet oxygen quantum yield depending on the stoichiometric ratio in the conjugate. In such a case the photodynamic effect was enhanced compared to phthalocyanine in the absence of nanodiamond. Results may be helpful for designing the third generation photosensitizers with nanoparticles that act as a platform for drug delivery.

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酞菁-纳米金刚石偶联机制及其对光动力活性的影响

在这项工作中，我们分析了水溶性带电金属酞菁与具有可变表面参数的纳米金刚石的非共价结合，并确定了两种共轭机制。第一个机制是π-π堆积导致酞菁荧光猝灭，单线态氧量子产率和A431细胞的光动力效率降低。第二种机制是通过静电相互作用实现的，保留了酞菁的荧光特性和可变的单线态氧量子产率，这取决于共轭物中的化学计量比。在这种情况下，与没有纳米金刚石的酞菁相比，光动力效应得到了增强。研究结果可能有助于设计第三代纳米光敏剂作为药物传递平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diamond and Related Materials 工程技术-材料科学：综合

CiteScore

6.00

自引率

14.60%

发文量

702

审稿时长

2.1 months

期刊介绍： DRM is a leading international journal that publishes new fundamental and applied research on all forms of diamond, the integration of diamond with other advanced materials and development of technologies exploiting diamond. The synthesis, characterization and processing of single crystal diamond, polycrystalline films, nanodiamond powders and heterostructures with other advanced materials are encouraged topics for technical and review articles. In addition to diamond, the journal publishes manuscripts on the synthesis, characterization and application of other related materials including diamond-like carbons, carbon nanotubes, graphene, and boron and carbon nitrides. Articles are sought on the chemical functionalization of diamond and related materials as well as their use in electrochemistry, energy storage and conversion, chemical and biological sensing, imaging, thermal management, photonic and quantum applications, electron emission and electronic devices. The International Conference on Diamond and Carbon Materials has evolved into the largest and most well attended forum in the field of diamond, providing a forum to showcase the latest results in the science and technology of diamond and other carbon materials such as carbon nanotubes, graphene, and diamond-like carbon. Run annually in association with Diamond and Related Materials the conference provides junior and established researchers the opportunity to exchange the latest results ranging from fundamental physical and chemical concepts to applied research focusing on the next generation carbon-based devices.