Emerging strategies to enhance microbial natural product–based drug discovery

IF 7 2区工程技术 Q1 BIOCHEMICAL RESEARCH METHODS

Current opinion in biotechnology Pub Date : 2025-10-10 DOI:10.1016/j.copbio.2025.103369

Michael Madden , Conor Pulliam , Katherine Holandez-Lopez , Andrew Campbell , Jie Li

引用次数: 0

Abstract

Natural products (NPs) have served as a major source of chemically novel, bioactive therapeutics for the treatment of various diseases. In recent years, NP discovery has benefited greatly from advancements in biotechnological fields. This review covers techniques and tools from 2022 to 2025 that have expanded NP discovery capabilities through gene-editing tools to activate silent biosynthetic genes, cell-free methods for NP production and diversification, as well as artificial intelligence and informatics tools for structure generation and correlational studies.

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新兴战略加强微生物天然产物为基础的药物发现

天然产物（NPs）已成为治疗各种疾病的新型化学生物活性疗法的主要来源。近年来，NP的发现得益于生物技术领域的进步。本文综述了从2022年到2025年的技术和工具，这些技术和工具通过基因编辑工具来激活沉默的生物合成基因，用于NP产生和多样化的无细胞方法，以及用于结构生成和相关研究的人工智能和信息学工具，扩大了NP发现能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in biotechnology 工程技术-生化研究方法

CiteScore

16.20

自引率

2.60%

发文量

226

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Biotechnology (COBIOT) is renowned for publishing authoritative, comprehensive, and systematic reviews. By offering clear and readable syntheses of current advances in biotechnology, COBIOT assists specialists in staying updated on the latest developments in the field. Expert authors annotate the most noteworthy papers from the vast array of information available today, providing readers with valuable insights and saving them time. As part of the Current Opinion and Research (CO+RE) suite of journals, COBIOT is accompanied by the open-access primary research journal, Current Research in Biotechnology (CRBIOT). Leveraging the editorial excellence, high impact, and global reach of the Current Opinion legacy, CO+RE journals ensure they are widely read resources integral to scientists' workflows. COBIOT is organized into themed sections, each reviewed once a year. These themes cover various areas of biotechnology, including analytical biotechnology, plant biotechnology, food biotechnology, energy biotechnology, environmental biotechnology, systems biology, nanobiotechnology, tissue, cell, and pathway engineering, chemical biotechnology, and pharmaceutical biotechnology.