Development and characterization of new dosimeter MAGIC-glutaraldehyde

IF 2.8 3区物理与天体物理 Q3 CHEMISTRY, PHYSICAL

Radiation Physics and Chemistry Pub Date : 2025-09-29 DOI:10.1016/j.radphyschem.2025.113340

S. Brahimi Moussa , W. Bellil

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Abstract

This study presents the development of an advanced dosimetry system designed to outperform the conventional MAGIC polymer gel dosimeter. By incorporating Glutaraldehyde (GLA) as a cross-linking agent and employing X-ray computed tomography (CT) for precise three-dimensional dose readout, the modified MAGIC-G.LA gel dosimeter offers enhanced performance in radiotherapy simulations. To establish a calibration curve for the new formulation, irradiation doses ranging from 2 to 12 Gy were applied. The dose–response relationship exhibited superior linearity compared to the traditional MAGIC gel, with the calibration curve showing an excellent fit to a linear model (R² = 0.99). This improved linearity and sensitivity prompted further structural analyses to investigate the underlying mechanisms. Results suggest that Glutaraldehyde significantly contributes to the gel's enhanced polymerization response and structural stability under radiation. These findings provide deeper insight into the radiation-induced polymerization process and underscore the potential of Glutaraldehyde in optimizing polymer gel dosimetry.

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新型剂量计magic -戊二醛的研制与表征

本研究提出了一种先进的剂量测定系统的发展，其设计优于传统的MAGIC聚合物凝胶剂量计。通过加入戊二醛（GLA）作为交联剂，并采用x射线计算机断层扫描（CT）精确的三维剂量读数，改进的MAGIC-G。LA凝胶剂量计在放射模拟中提供了增强的性能。为了建立新配方的校准曲线，辐照剂量范围为2 ~ 12 Gy。与传统MAGIC凝胶相比，剂量-反应关系具有良好的线性关系，校准曲线与线性模型拟合良好（R2 = 0.99）。这种改进的线性和灵敏度促使进一步的结构分析来研究潜在的机制。结果表明，戊二醛显著提高了凝胶在辐射下的聚合反应和结构稳定性。这些发现为辐射诱导聚合过程提供了更深入的见解，并强调了戊二醛在优化聚合物凝胶剂量学方面的潜力。

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来源期刊

Radiation Physics and Chemistry 化学-核科学技术

CiteScore

5.60

自引率

17.20%

发文量

574

审稿时长

12 weeks

期刊介绍： Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.