Utility of biological aging acceleration in capturing transitions of atrial fibrillation and dementia: a population-based study.

IF 6 Q2 GERIATRICS & GERONTOLOGY
Yufan Liu, Chenglong Li
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引用次数: 0

Abstract

The biological aging acceleration predicts both morbidity and mortality, while few investigations have examined its utility in evaluating transitions, e.g. development patterns, of atrial fibrillation (AF) and dementia. We aimed to investigate the utility of biological aging acceleration in predicting transitions of AF and dementia. A total of 402,955 participants (mean [SD] age: 56.5 [8.1] years; men: 45.9%) in the UK Biobank were included. Biological age was calculated using the phenotypic age, based on the chronological age and 9 biomarkers. A multi-state survival analysis was conducted to examine transition patterns between AF and dementia. The increased biological aging acceleration was consistently associated with all transition patterns between AF and dementia, including transitions from incident AF or dementia to the comorbidity. Strong linear associations were observed. Our findings highlight the overlooked utility of biological aging acceleration in evaluating the transitions of AF and dementia in the general population.

利用生物老化加速捕捉心房颤动和痴呆的转变:一项基于人群的研究。
生物老化加速可以预测发病率和死亡率,但很少有研究检查其在评估房颤(AF)和痴呆的转变(例如发展模式)方面的效用。我们的目的是研究生物老化加速在预测房颤和痴呆转变中的作用。英国生物银行共纳入402,955名参与者(平均[SD]年龄:56.5[8.1]岁;男性:45.9%)。生物学年龄是根据实足年龄和9个生物标志物计算的表型年龄。进行多状态生存分析以检查房颤和痴呆之间的过渡模式。增加的生物衰老加速与房颤和痴呆之间的所有过渡模式一致相关,包括从事件房颤或痴呆到合并症的过渡。观察到强烈的线性关联。我们的研究结果强调了在评估普通人群房颤和痴呆的转变时被忽视的生物衰老加速的效用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
8.90
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