Association Between Digestive Diseases, Nighttime Sleep, and Depressive Symptoms Among the Middle-Aged and Elderly Adults: A Mediation Analysis.

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY

JGH Open Pub Date : 2025-10-08 eCollection Date: 2025-10-01 DOI:10.1002/jgh3.70294

Congcong Cheng, Dinghui Guo, Xu Cao, Dingmin Wang, Wenling Li, Bei Miao, Sujuan Fei

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Abstract

Objective: To explore the mediating effect of nighttime sleep duration between digestive diseases and depressive symptoms among middle-aged and elderly adults, so as to guide clinical intervention and treatment of depression related to digestive diseases.

Methods: Based on the data of the China Health and Retirement Longitudinal Study (CHARLS) from 2015 to 2020, difference analysis, Spearman correlation analysis, and multivariate logistic regression were conducted to analyze the relationships among digestive diseases, nighttime sleep duration, and depressive symptoms. The mediating effect model was established and tested by the Bootstrap method.

Results: The prevalence rate of digestive diseases was 23.05%, and the detection rate of depressive symptoms was 35.90%. Correlation and regression analysis indicated that digestive diseases (OR = 1.62, 95% CI: 1.45-1.81) and insufficient nighttime sleep (OR = 2.22, 95% CI: 2.01-2.45) significantly impacted depressive symptoms. The results of the mediating effect model showed that insufficient nighttime sleep had a partial mediating effect between digestive diseases and depressive symptoms among middle-aged and elderly adults.

Conclusion: Digestive diseases can lead to insufficient nighttime sleep and promote the occurrence of depressive symptoms among middle-aged and elderly adults. Therefore, in clinical practice, when treating digestive patients with comorbid depression, the quality and duration of their nighttime sleep should not be ignored. Improving sleep conditions is expected to alleviate depressive symptoms.

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中老年人消化系统疾病、夜间睡眠和抑郁症状之间的关联：一项中介分析

目的：探讨夜间睡眠时间在中老年人消化系统疾病与抑郁症状之间的中介作用，以指导消化系统疾病相关抑郁的临床干预和治疗。方法：基于2015 - 2020年中国健康与退休纵向研究（CHARLS）数据，采用差异分析、Spearman相关分析和多因素logistic回归分析消化系统疾病与夜间睡眠时间、抑郁症状之间的关系。建立了中介效应模型，并采用Bootstrap方法进行了检验。结果：消化系统疾病检出率为23.05%，抑郁症状检出率为35.90%。相关和回归分析显示，消化系统疾病（OR = 1.62, 95% CI: 1.45-1.81）和夜间睡眠不足（OR = 2.22, 95% CI: 2.01-2.45）显著影响抑郁症状。中介效应模型结果显示，夜间睡眠不足在中老年人消化系统疾病与抑郁症状之间具有部分中介作用。结论：消化系统疾病可导致中老年人群夜间睡眠不足，促进抑郁症状的发生。因此，在临床实践中，在治疗消化道合并抑郁症患者时，其夜间睡眠质量和持续时间不容忽视。改善睡眠条件有望减轻抑郁症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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