Infectious etiologies of conjunctival tumors.

IF 0.9 Q4 OPHTHALMOLOGY

Expert Review of Ophthalmology Pub Date : 2025-01-01 Epub Date: 2024-09-11 DOI:10.1080/17469899.2024.2396926

Osmel P Alvarez, David Monroy, Soraiya Thura, Michael Antonietti, Sohaib Fasih-Ahmad, Paula A Sepulveda-Beltran, Sara Culbertson, Sander R Dubovy, Anat Galor, Carol L Karp

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引用次数: 0

Abstract

Introduction: Infectious agents have been associated with a variety of conjunctival tumors, including lymphoma, ocular surface squamous neoplasia (OSSN), papilloma, and Kaposi sarcoma.

Areas covered: We discuss the infectious etiologies of certain conjunctival tumors including conjunctival lymphoma (Chlamydia spp. Helicobacter pylori, Epstein-Barr virus, hepatitis C virus), OSSN (human papillomavirus, human immunodeficiency virus), papilloma (human papilloma virus), and Kaposi sarcoma (Kaposi sarcoma herpesvirus). Their respective oncogenic mechanisms, diagnosis, and treatment options are reviewed.

Expert opinion: It is important for the clinician to recognize when tumors of the conjunctiva may be infection-associated. A detailed history and exam are the most important first step in diagnosis; this may be supplemented by tools such as high-resolution optical coherence tomography. For some tumors, the specific causative agent may influence treatment options and outcomes. For others, data suggest the infectious agent does not influence treatment or outcomes, but it is important nonetheless to be aware as further research on these tumors continues. Additionally, there is exciting research investigating novel and minimally invasive diagnostic and treatment options for conjunctival tumors, including treatments that target the infectious agent directly.

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结膜肿瘤的感染病因。

传染性病原体与多种结膜肿瘤有关，包括淋巴瘤、眼表鳞状瘤（OSSN）、乳头状瘤和卡波西肉瘤。涵盖领域：我们讨论某些结膜肿瘤的感染病因，包括结膜淋巴瘤（衣原体、幽门螺杆菌、爱泼斯坦-巴尔病毒、丙型肝炎病毒）、OSSN（人乳头瘤病毒、人类免疫缺陷病毒）、乳头瘤（人乳头瘤病毒）和卡波西肉瘤（卡波西肉瘤疱疹病毒）。本文综述了它们各自的致癌机制、诊断和治疗方案。专家意见：对于临床医生来说，认识到结膜肿瘤何时可能与感染有关是很重要的。详细的病史和检查是诊断最重要的第一步；这可以通过诸如高分辨率光学相干层析成像之类的工具加以补充。对于某些肿瘤，特定的致病因子可能会影响治疗方案和结果。对于其他人来说，数据表明感染源不会影响治疗或结果，但重要的是要意识到对这些肿瘤的进一步研究仍在继续。此外，还有一些令人兴奋的研究正在探索结膜肿瘤的新型微创诊断和治疗方案，包括直接针对感染因子的治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Ophthalmology Health Professions-Optometry

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The worldwide problem of visual impairment is set to increase, as we are seeing increased longevity in developed countries. This will produce a crisis in vision care unless concerted action is taken. The substantial value that ophthalmic interventions confer to patients with eye diseases has led to intense research efforts in this area in recent years, with corresponding improvements in treatment, ophthalmic instrumentation and surgical techniques. As a result, the future for ophthalmology holds great promise as further exciting and innovative developments unfold.