Elahe Etesami, Ali Nikparast, Matin Ghanavati, Seyed Ali Keshavarz
{"title":"Dairy products consumption linked to decreased risk of endometrial cancer: A case-control study.","authors":"Elahe Etesami, Ali Nikparast, Matin Ghanavati, Seyed Ali Keshavarz","doi":"10.1038/s41598-025-17063-5","DOIUrl":null,"url":null,"abstract":"<p><p>Evidence remains inconsistent regarding the relationship between dairy products consumption and endometrial cancer (EC) risk. This study aimed to investigate the association between dairy products intake and EC risk in Iranian women. In this hospital-based case-control study, 136 patients with histologically confirmed EC and 272 age- and BMI-matched controls were included. Dietary intake was assessed by a validated 168-item food frequency questionnaire. Conditional logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for EC risk across tertiles of energy-adjusted dairy consumption, adjusting for relevant dietary, reproductive, and lifestyle confounders. Higher intake of total dairy, low-fat dairy, and high-fat dairy was significantly associated with a lower risk of EC in fully adjusted models. The strongest inverse associations were observed at moderate intake levels. No significant association was found between butter consumption and EC risk. Sensitivity analyses among postmenopausal women confirmed consistent inverse associations for total and subtypes of dairy products. Our study indicated that higher dairy product consumption is associated with a reduced risk of EC. These findings suggest a potential protective role of dairy in EC prevention. Additional research, particularly in larger and more diverse populations, is needed to explore this further.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35271"},"PeriodicalIF":3.9000,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12511616/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scientific Reports","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1038/s41598-025-17063-5","RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Evidence remains inconsistent regarding the relationship between dairy products consumption and endometrial cancer (EC) risk. This study aimed to investigate the association between dairy products intake and EC risk in Iranian women. In this hospital-based case-control study, 136 patients with histologically confirmed EC and 272 age- and BMI-matched controls were included. Dietary intake was assessed by a validated 168-item food frequency questionnaire. Conditional logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for EC risk across tertiles of energy-adjusted dairy consumption, adjusting for relevant dietary, reproductive, and lifestyle confounders. Higher intake of total dairy, low-fat dairy, and high-fat dairy was significantly associated with a lower risk of EC in fully adjusted models. The strongest inverse associations were observed at moderate intake levels. No significant association was found between butter consumption and EC risk. Sensitivity analyses among postmenopausal women confirmed consistent inverse associations for total and subtypes of dairy products. Our study indicated that higher dairy product consumption is associated with a reduced risk of EC. These findings suggest a potential protective role of dairy in EC prevention. Additional research, particularly in larger and more diverse populations, is needed to explore this further.
期刊介绍：
We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections.
Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021).
•Engineering
Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live.
•Physical sciences
Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics.
•Earth and environmental sciences
Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems.
•Biological sciences
Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants.
•Health sciences
The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
