Optimizing breast cancer chemotherapy by harnessing gut microbiota with insights from artificial intelligence.

IF 9.2 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

npj Biofilms and Microbiomes Pub Date : 2025-10-09 DOI:10.1038/s41522-025-00825-4

Yi Zhou, Min Jiang, Ke Shen, Tao He, Siyu Zhou, Aibin Shao, Xiaoyu Li, Jiao Wang, Rongrong Wu, Rajeev K Singla, Jonathan P Jacobs, Bairong Shen

引用次数: 0

Abstract

Optimizing chemotherapy for breast cancer (BC) remains a critical challenge. Gut microbiota (GM) dysbiosis, varying across BC subtypes and stages, influences BC development and chemotherapy response through immune and metabolic pathways. Chemotherapy also disrupts the microbiota, creating a complex bidirectional interaction. Integrating artificial intelligence (AI) allows the identification of hidden patterns, deepening our understanding of the microbiota's role. This integrated approach promises to revolutionize BC treatment with novel insights and personalized interventions.

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利用人工智能的洞察力利用肠道微生物群优化乳腺癌化疗。

优化乳腺癌（BC）化疗仍然是一个关键的挑战。肠道微生物群（GM）生态失调，因BC亚型和分期而异，通过免疫和代谢途径影响BC的发展和化疗反应。化疗也会破坏微生物群，产生复杂的双向相互作用。整合人工智能（AI）可以识别隐藏的模式，加深我们对微生物群作用的理解。这种综合方法有望通过新颖的见解和个性化的干预措施彻底改变BC治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.