Bridging the Nervous-Endocrine System and Immune Response, in Human Chagas Disease Pathology.

IF 3.7 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Neuroimmunomodulation Pub Date : 2025-01-01 Epub Date: 2025-10-08 DOI:10.1159/000548813

Florencia Belén González, Brenda Dinatale, Wilson Savino, Oscar Adelmo Bottasso, Ana Rosa Pérez

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Abstract

Background: Chronic Chagas disease can affect multiple organs, most notably the heart and gastrointestinal tract, and in some cases, the nervous system. However, the underlying pathophysiological mechanisms of this parasitic infection remain incompletely understood. Summary: Evidence from studies in both mice with acute Trypanosoma cruzi (T. cruzi) infection and in patients with Chagas disease has revealed a range of immune-neuroendocrine alterations and metabolic disruptions. In this review, we highlight key findings in human Chagas disease related to these abnormalities and discuss their potential contributions to disease pathogenesis. Key Messages: In the context of chronic Chagas disease, the neuroendocrine-immune axis operates as a dynamic interface, integrating systemic immune-endocrine processes with localized responses in the central nervous system (CNS), with each component influencing disease advancement and organ-specific pathology through distinct yet interconnected mechanisms.

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人类恰加斯病病理中神经内分泌系统与免疫反应的桥接。

慢性恰加斯病可影响多个器官，最明显的是心脏和胃肠道，在某些情况下，还会影响神经系统。然而，这种寄生虫感染的潜在病理生理机制仍然不完全清楚。来自急性克氏锥虫感染小鼠和恰加斯病患者的研究证据显示，存在一系列免疫-神经内分泌改变和代谢紊乱。在这篇综述中，我们重点介绍了在人类恰加斯病中与这些异常相关的关键发现，并讨论了它们对疾病发病机制的潜在贡献。

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来源期刊

Neuroimmunomodulation 医学-免疫学

CiteScore

3.60

自引率

4.20%

发文量

审稿时长

>12 weeks

期刊介绍： The rapidly expanding area of research known as neuroimmunomodulation explores the way in which the nervous system interacts with the immune system via neural, hormonal, and paracrine actions. Encompassing both basic and clinical research, ''Neuroimmunomodulation'' reports on all aspects of these interactions. Basic investigations consider all neural and humoral networks from molecular genetics through cell regulation to integrative systems of the body. The journal also aims to clarify the basic mechanisms involved in the pathogenesis of the CNS pathology in AIDS patients and in various neurodegenerative diseases. Although primarily devoted to research articles, timely reviews are published on a regular basis.