Faisal A A Shurafa, Kevin M Klifto, Stephen J Kovach, L Scott Levin, Saïd C Azoury
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引用次数: 0
Abstract
Vascularized composite allotransplantation (VCA) has all the immunogenic risks of solid organ transplantation, while including the complexity and immunogenicity of the skin. This review provides an overview of the human leukocyte antigens (HLAs) system and its current role in VCA. HLA are cell surface glycoproteins critical for immune system surveillance. Their physiological function is to present self-recognized and foreign peptides to inhibit or initiate an immune response through induction, regulation of immune responses, and the selection of T-cells. The HLA system provides targets for stimulation during graft versus host disease, donor-specific HLA antibodies, and allograft rejection. HLA matching, identifying and using acceptable mismatches, and desensitization strategies may increase the immunologic compatibility of the HLA system between a donor and recipient in VCA.
期刊介绍：
The Journal of Surgical Research: Clinical and Laboratory Investigation publishes original articles concerned with clinical and laboratory investigations relevant to surgical practice and teaching. The journal emphasizes reports of clinical investigations or fundamental research bearing directly on surgical management that will be of general interest to a broad range of surgeons and surgical researchers. The articles presented need not have been the products of surgeons or of surgical laboratories.
The Journal of Surgical Research also features review articles and special articles relating to educational, research, or social issues of interest to the academic surgical community.
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