{"title":"Emerging paradigms in bioorthogonal chemistry for future therapeutics.","authors":"Maide Önder, Fatma Zehra Yılmaz, Zeynep Demirsoy, Gülcihan Gülseren","doi":"10.1016/j.ijpharm.2025.126236","DOIUrl":null,"url":null,"abstract":"<p><p>Bioorthogonal chemistry, referring to chemical reactions that can occur within living systems without interfering with native biological processes, provides a safe and specific method for labeling or linking biomolecules with rapid and efficient reaction kinetics. To date, various bioorthogonal reactions, such as Staudinger Ligation, copper-catalyzed azide-alkyne cycloaddition (CuAAC), copper-free azide-alkyne cycloaddition (SPAAC), and the inverse electron-demand Diels-Alder (IEDDA) reaction, have been developed to achieve improved safety and efficacy. These advanced bioorthogonal reactions have enabled the emergence of innovative treatment strategies for diseases such as cancer, neurodegenerative disorders, ischemia, cardiac hypertrophy, and bacterial infections. Beyond disease treatment, bioorthogonal chemistry has also contributed to the development of advanced diagnostic materials. This review highlights the therapeutic, regenerative, and diagnostic applications of bioorthogonal chemistry.</p>","PeriodicalId":14187,"journal":{"name":"International Journal of Pharmaceutics","volume":" ","pages":"126236"},"PeriodicalIF":5.2000,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Pharmaceutics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ijpharm.2025.126236","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Bioorthogonal chemistry, referring to chemical reactions that can occur within living systems without interfering with native biological processes, provides a safe and specific method for labeling or linking biomolecules with rapid and efficient reaction kinetics. To date, various bioorthogonal reactions, such as Staudinger Ligation, copper-catalyzed azide-alkyne cycloaddition (CuAAC), copper-free azide-alkyne cycloaddition (SPAAC), and the inverse electron-demand Diels-Alder (IEDDA) reaction, have been developed to achieve improved safety and efficacy. These advanced bioorthogonal reactions have enabled the emergence of innovative treatment strategies for diseases such as cancer, neurodegenerative disorders, ischemia, cardiac hypertrophy, and bacterial infections. Beyond disease treatment, bioorthogonal chemistry has also contributed to the development of advanced diagnostic materials. This review highlights the therapeutic, regenerative, and diagnostic applications of bioorthogonal chemistry.
期刊介绍：
The International Journal of Pharmaceutics is the third most cited journal in the "Pharmacy & Pharmacology" category out of 366 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.
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