{"title":"A bibliometric analysis of the current state and future directions of osteoporosis pharmacological treatment.","authors":"Xianxian Zhou, Hua Xiong, Dexi Hu","doi":"10.3389/fmed.2025.1622425","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Osteoporosis is a major health threat, particularly with the aging population in China. Medication remains a cornerstone of management, and bibliometric analysis can provide insights into current research status and future directions.</p><p><strong>Methods: </strong>Relevant literature from the Science Citation Index Core Collection (2015-2024) was analyzed using bibliometric methods. Visual maps were generated with Citespace 6.3R3 and VOSviewer 1.6.19 to assess research trends and hotspots.</p><p><strong>Results: </strong>A total of 2,738 publications were included, showing a steady growth in research since 2015. The United States led in output, with the University of Toronto as the most productive institution. Brandi, Maria Luisa, and Kanis JA were the most influential authors, while Osteoporosis International and The Journal of Bone and Mineral Research were the most cited journals. Key themes included extracellular vesicles, romosozumab, bisphosphonates, and breast cancer, with recent attention on targeted drug delivery, treatment efficacy, and medication management. Emerging keywords from 2022 to 2023, such as exosomes, inflammation, and osteogenic differentiation, reflected advances in therapeutic mechanisms and clinical applications.</p><p><strong>Conclusion: </strong>Future research will likely emphasize targeted drug delivery, clinical efficacy and safety, and molecular targeted therapies, with the development of new anti-osteoporosis drugs remaining a key focus.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1622425"},"PeriodicalIF":3.1000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504286/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fmed.2025.1622425","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Osteoporosis is a major health threat, particularly with the aging population in China. Medication remains a cornerstone of management, and bibliometric analysis can provide insights into current research status and future directions.
Methods: Relevant literature from the Science Citation Index Core Collection (2015-2024) was analyzed using bibliometric methods. Visual maps were generated with Citespace 6.3R3 and VOSviewer 1.6.19 to assess research trends and hotspots.
Results: A total of 2,738 publications were included, showing a steady growth in research since 2015. The United States led in output, with the University of Toronto as the most productive institution. Brandi, Maria Luisa, and Kanis JA were the most influential authors, while Osteoporosis International and The Journal of Bone and Mineral Research were the most cited journals. Key themes included extracellular vesicles, romosozumab, bisphosphonates, and breast cancer, with recent attention on targeted drug delivery, treatment efficacy, and medication management. Emerging keywords from 2022 to 2023, such as exosomes, inflammation, and osteogenic differentiation, reflected advances in therapeutic mechanisms and clinical applications.
Conclusion: Future research will likely emphasize targeted drug delivery, clinical efficacy and safety, and molecular targeted therapies, with the development of new anti-osteoporosis drugs remaining a key focus.
期刊介绍：
Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate
- the use of patient-reported outcomes under real world conditions
- the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines
- the scientific bases for guidelines and decisions from regulatory authorities
- access to medicinal products and medical devices worldwide
- addressing the grand health challenges around the world
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