Fibrinogen glycosylation and glycation: molecular insights into thrombosis and vascular disease.

IF 3.9 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Frontiers in Molecular Biosciences Pub Date : 2025-09-24 eCollection Date: 2025-01-01 DOI:10.3389/fmolb.2025.1680332

Serena Borghi, Francesca Nencini, Elvira Giurranna, Ilenia Barbaro, Niccolò Taddei, Claudia Fiorillo, Matteo Becatti

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Abstract

Fibrinogen, a key protein in blood coagulation, undergoes two distinct post-translational modifications (PTMs): glycosylation and glycation. Glycosylation is an enzymatic, tightly regulated process, whereas glycation occurs non-enzymatically under hyperglycemic conditions. Emerging evidence highlights the role of these modifications in cardiovascular risk. This review provides a comprehensive overview of how fibrinogen glycosylation and glycation contribute to altered haemostatic profiles and increased cardiovascular risk. Evidence is presented from inherited fibrinogen disorders, liver disease, diabetes, and chronic conditions such as end-stage renal disease. Additionally, the potential use of glycosylation and glycation patterns as diagnostic or prognostic biomarkers in cardiovascular disease is discussed. Overall, changes in fibrinogen's glycosylation and glycation profiles may serve as important markers for cardiovascular risk assessment in many diseases, offering insights into the molecular mechanisms underlying these conditions.

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纤维蛋白原糖基化和糖基化：血栓和血管疾病的分子洞察。

纤维蛋白原是血液凝固过程中的关键蛋白，它经历了两种不同的翻译后修饰（PTMs）：糖基化和糖基化。糖基化是一个酶促的、严格调控的过程，而糖基化在高血糖条件下是非酶促的。新出现的证据强调了这些改变在心血管风险中的作用。这篇综述全面概述了纤维蛋白原糖基化和糖基化是如何改变止血特征和增加心血管风险的。证据来自遗传性纤维蛋白原疾病、肝病、糖尿病和慢性疾病，如终末期肾病。此外，还讨论了糖基化和糖基化模式作为心血管疾病诊断或预后生物标志物的潜在用途。总之，纤维蛋白原糖基化和糖基化谱的变化可以作为许多疾病心血管风险评估的重要标志，为这些疾病的分子机制提供见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Molecular Biosciences Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

7.20

自引率

4.00%

发文量

1361

审稿时长

14 weeks

期刊介绍： Much of contemporary investigation in the life sciences is devoted to the molecular-scale understanding of the relationships between genes and the environment — in particular, dynamic alterations in the levels, modifications, and interactions of cellular effectors, including proteins. Frontiers in Molecular Biosciences offers an international publication platform for basic as well as applied research; we encourage contributions spanning both established and emerging areas of biology. To this end, the journal draws from empirical disciplines such as structural biology, enzymology, biochemistry, and biophysics, capitalizing as well on the technological advancements that have enabled metabolomics and proteomics measurements in massively parallel throughput, and the development of robust and innovative computational biology strategies. We also recognize influences from medicine and technology, welcoming studies in molecular genetics, molecular diagnostics and therapeutics, and nanotechnology. Our ultimate objective is the comprehensive illustration of the molecular mechanisms regulating proteins, nucleic acids, carbohydrates, lipids, and small metabolites in organisms across all branches of life. In addition to interesting new findings, techniques, and applications, Frontiers in Molecular Biosciences will consider new testable hypotheses to inspire different perspectives and stimulate scientific dialogue. The integration of in silico, in vitro, and in vivo approaches will benefit endeavors across all domains of the life sciences.