Sustainable biosynthesis, physiochemical characterization, cytotoxicity, and antimicrobial evaluation of novel chromium oxide nanoparticles.

IF 4.2 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Frontiers in Chemistry Pub Date : 2025-09-24 eCollection Date: 2025-01-01 DOI:10.3389/fchem.2025.1584199

Ezzat H Elshazly, G Abd Elfadeel, Lihang Yang, Xiqi Li, Emad A Ewais, Ahmed M Sadek, Taher M Taha, Omar Fathy, Omar Mohammad Atta, Wen-Zong Liu

{"title":"Sustainable biosynthesis, physiochemical characterization, cytotoxicity, and antimicrobial evaluation of novel chromium oxide nanoparticles.","authors":"Ezzat H Elshazly, G Abd Elfadeel, Lihang Yang, Xiqi Li, Emad A Ewais, Ahmed M Sadek, Taher M Taha, Omar Fathy, Omar Mohammad Atta, Wen-Zong Liu","doi":"10.3389/fchem.2025.1584199","DOIUrl":null,"url":null,"abstract":"The biosynthesis of nanoparticles (NPs) has attracted significant interest due to their diverse biological applications. However, the potential for NPs synthesis using plant resources from Vicia monantha Retz remains largely unexplored. Notably, this study marks the first use of this specific plant for the biosynthesis of chromium oxide nanoparticles (Cr2O3NPs). In the present study, the single phase of Cr2O3 was confirmed at a calcination temperature 700 °C for the synthesized NPs. The crystallite sizes increased from 14 nm to 20 nm with the increase in the calcination temperature to 900 °C for 2 h. Ultraviolet-visible (UV-VIS) light spectroscopy revealed that the samples are semiconductor materials, according to the observed values of energy band gap. The developed Cr2O3NPs did not show any toxicity toward NIH-3T3 fibroblasts. The results demonstrated that Cr2O3NPs exhibited good antimicrobial activity against two bacterial strains (Escherichia coli and Staphylococcus aureus) and two fungal strains (Candida albicans and Aspergillus sp.), producing clear inhibition zones of 0.26 cm, 0.21 cm, 0.28 cm, and 0.3 cm, respectively, after 24 h. The Cr2O3NPs exhibit successful green synthesis, notable biocompatibility, and antimicrobial properties, making them highly promising for various applications and opening possibilities for the utilization of nanoparticles in antimicrobial systems.","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1584199"},"PeriodicalIF":4.2000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504197/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.3389/fchem.2025.1584199","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

The biosynthesis of nanoparticles (NPs) has attracted significant interest due to their diverse biological applications. However, the potential for NPs synthesis using plant resources from Vicia monantha Retz remains largely unexplored. Notably, this study marks the first use of this specific plant for the biosynthesis of chromium oxide nanoparticles (Cr₂O₃NPs). In the present study, the single phase of Cr₂O₃ was confirmed at a calcination temperature 700 °C for the synthesized NPs. The crystallite sizes increased from 14 nm to 20 nm with the increase in the calcination temperature to 900 °C for 2 h. Ultraviolet-visible (UV-VIS) light spectroscopy revealed that the samples are semiconductor materials, according to the observed values of energy band gap. The developed Cr₂O₃NPs did not show any toxicity toward NIH-3T3 fibroblasts. The results demonstrated that Cr₂O₃NPs exhibited good antimicrobial activity against two bacterial strains (Escherichia coli and Staphylococcus aureus) and two fungal strains (Candida albicans and Aspergillus sp.), producing clear inhibition zones of 0.26 cm, 0.21 cm, 0.28 cm, and 0.3 cm, respectively, after 24 h. The Cr₂O₃NPs exhibit successful green synthesis, notable biocompatibility, and antimicrobial properties, making them highly promising for various applications and opening possibilities for the utilization of nanoparticles in antimicrobial systems.

Abstract Image

查看原文本刊更多论文

新型氧化铬纳米颗粒的可持续生物合成、物理化学表征、细胞毒性和抗菌评价。

纳米颗粒的生物合成由于其广泛的生物学应用而引起了人们的极大兴趣。然而，利用紫杉属植物资源合成NPs的潜力仍未得到充分开发。值得注意的是，这项研究标志着该特定植物首次用于氧化铬纳米颗粒（Cr2O3NPs）的生物合成。在本研究中，合成的纳米粒子在700°C的煅烧温度下证实了Cr2O3的单相。当煅烧温度提高到900℃，煅烧2 h，晶体尺寸从14 nm增大到20 nm。紫外可见光谱（UV-VIS）显示样品为半导体材料，根据能带隙的观测值。开发的Cr2O3NPs对NIH-3T3成纤维细胞没有任何毒性。结果表明，Cr2O3NPs对两种细菌（大肠杆菌和金黄色葡萄球菌）和两种真菌（白色念珠菌和曲霉）具有良好的抑菌活性，24 h后分别产生0.26 cm、0.21 cm、0.28 cm和0.3 cm的清晰抑菌区。这使得它们在各种应用中具有很高的前景，并为纳米颗粒在抗菌系统中的应用开辟了可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Chemistry Chemistry-General Chemistry

CiteScore

8.50

自引率

3.60%

发文量

1540

审稿时长

12 weeks

期刊介绍： Frontiers in Chemistry is a high visiblity and quality journal, publishing rigorously peer-reviewed research across the chemical sciences. Field Chief Editor Steve Suib at the University of Connecticut is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to academics, industry leaders and the public worldwide. Chemistry is a branch of science that is linked to all other main fields of research. The omnipresence of Chemistry is apparent in our everyday lives from the electronic devices that we all use to communicate, to foods we eat, to our health and well-being, to the different forms of energy that we use. While there are many subtopics and specialties of Chemistry, the fundamental link in all these areas is how atoms, ions, and molecules come together and come apart in what some have come to call the “dance of life”. All specialty sections of Frontiers in Chemistry are open-access with the goal of publishing outstanding research publications, review articles, commentaries, and ideas about various aspects of Chemistry. The past forms of publication often have specific subdisciplines, most commonly of analytical, inorganic, organic and physical chemistries, but these days those lines and boxes are quite blurry and the silos of those disciplines appear to be eroding. Chemistry is important to both fundamental and applied areas of research and manufacturing, and indeed the outlines of academic versus industrial research are also often artificial. Collaborative research across all specialty areas of Chemistry is highly encouraged and supported as we move forward. These are exciting times and the field of Chemistry is an important and significant contributor to our collective knowledge.