{"title":"Left-right symmetry breaking: learning from the chicken.","authors":"Tobias Karl Pieper, Nikoloz Tsikolia","doi":"10.3389/fcell.2025.1672263","DOIUrl":null,"url":null,"abstract":"<p><p>Morphological left-right asymmetry of visceral organs in most cases reveals a typical arrangement. This implies directed symmetry breaking which is suggested to be based on the existence of structural chirality. At early developmental stages many vertebrate model organisms display so-called leftward flow of extracellular fluid which is based on the unidirectional rotation of chiral cilia. Cytoskeletal chirality has been shown to contribute to the left-right asymmetry of invertebrates including <i>Caenorhabditis elegans</i> and <i>Drosophila melanogaster</i>. The mechanisms of left-right symmetry breaking in vertebrates without ciliary flow remain mysterious. Here, we present our perspective on left-right patterning and symmetry breaking in the chick within a broader context.</p>","PeriodicalId":12448,"journal":{"name":"Frontiers in Cell and Developmental Biology","volume":"13 ","pages":"1672263"},"PeriodicalIF":4.6000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504268/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Cell and Developmental Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3389/fcell.2025.1672263","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Morphological left-right asymmetry of visceral organs in most cases reveals a typical arrangement. This implies directed symmetry breaking which is suggested to be based on the existence of structural chirality. At early developmental stages many vertebrate model organisms display so-called leftward flow of extracellular fluid which is based on the unidirectional rotation of chiral cilia. Cytoskeletal chirality has been shown to contribute to the left-right asymmetry of invertebrates including Caenorhabditis elegans and Drosophila melanogaster. The mechanisms of left-right symmetry breaking in vertebrates without ciliary flow remain mysterious. Here, we present our perspective on left-right patterning and symmetry breaking in the chick within a broader context.
期刊介绍：
Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board.
The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology.
With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.
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