Optogenetics as a useful tool to control excitable and non-excitable tissues during chicken embryogenesis

Abstract

Optogenetics, a modern tool to control cellular excitability in a non-invasive way, has widely been used in neuroscience. Recently, optogenetic approaches begin to be applied to studies of other biological phenomena including muscle functions. For these analyses, chicken embryos serve as an excellent model animal since they are highly amenable to site-specific manipulations with genes of optogenetics such as Channelrhodopsins, and its following targeted light irradiation. We here overview recent progresses in optogenetics using chicken embryos with a highlight on the studies of axon pathfinding, gut peristalsis, and feather morphogenesis.