Effect of lacticaseibacillus paracasei PS23 on anxiety and sleep difficulties among office workers: a double-blind, randomized controlled pilot trial.

IF 3.6 3区医学 Q1 PSYCHIATRY

Annals of General Psychiatry Pub Date : 2025-10-09 DOI:10.1186/s12991-025-00599-1

Shu-I Wu, Kai-Liang Kao, Chen-Ju Lin, Ya-Ju Lin, I-Chieh Lin, Wan-Lin Chen

{"title":"Effect of lacticaseibacillus paracasei PS23 on anxiety and sleep difficulties among office workers: a double-blind, randomized controlled pilot trial.","authors":"Shu-I Wu, Kai-Liang Kao, Chen-Ju Lin, Ya-Ju Lin, I-Chieh Lin, Wan-Lin Chen","doi":"10.1186/s12991-025-00599-1","DOIUrl":null,"url":null,"abstract":"Background: Over the past decade, sleep disturbances and stress have markedly increased within the general population. Conditions such as insomnia and poor stress management are linked to a range of physical and psychological symptoms, including cardiovascular diseases, sleep disorders, depression, or anxiety. Recent studies have shown that heat-treated Lacticaseibacillus paracasei PS23 (PS23) can alleviate anxiety in clinical nurses experiencing high stress. However, the potential benefits of live PS23- particularly its effects on sleep quality, anxiety, and stress- remain unexplored.Methods: This study recruited office workers aged 20-65 years who reported moderate to high levels of perceived stress. Participants in the intervention group received a daily dose of 20 billion colony-forming units of live PS23 for six weeks, while the control group received two placebo capsules containing microcrystalline cellulose powder. Outcomes were assessed at baseline and at the end of the trial, including measures of stress, anxiety, sleep quality, fatigue, activity levels, depression, and overall quality of life. Additionally, changes in salivary stress markers and antioxidant levels were evaluated.Results: Of the 50 eligible participants initially enrolled, 45 completed the six-week trial with high compliance (> 80%), including 24 in the PS23 group and 21 in the placebo group. Compared to the placebo group, the PS23 group showed statistically significant improvements in overall insomnia symptoms (group × time interaction, p = 0.011), sleep latency (p = 0.045), sleep maintenance (p = 0.002), and trait anxiety levels (group × time interaction, p = 0.044).Conclusion: This pilot randomized controlled trial suggests that live L. paracasei PS23 may offer meaningful improvements in sleep quality and anxiety reduction among office workers experiencing elevated stress levels.Registration: ClinicalTrials.gov Identifier: NCT05826704; registration date: 4/11/2023. Exploring the Effects of Lactobacillus paracasei PS23 on Workplace-related Stress Symptoms Among Office Workers; URL: https://clinicaltrials.gov/study/NCT05826704.","PeriodicalId":7942,"journal":{"name":"Annals of General Psychiatry","volume":"24 1","pages":"59"},"PeriodicalIF":3.6000,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512398/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of General Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12991-025-00599-1","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Over the past decade, sleep disturbances and stress have markedly increased within the general population. Conditions such as insomnia and poor stress management are linked to a range of physical and psychological symptoms, including cardiovascular diseases, sleep disorders, depression, or anxiety. Recent studies have shown that heat-treated Lacticaseibacillus paracasei PS23 (PS23) can alleviate anxiety in clinical nurses experiencing high stress. However, the potential benefits of live PS23- particularly its effects on sleep quality, anxiety, and stress- remain unexplored.

Methods: This study recruited office workers aged 20-65 years who reported moderate to high levels of perceived stress. Participants in the intervention group received a daily dose of 20 billion colony-forming units of live PS23 for six weeks, while the control group received two placebo capsules containing microcrystalline cellulose powder. Outcomes were assessed at baseline and at the end of the trial, including measures of stress, anxiety, sleep quality, fatigue, activity levels, depression, and overall quality of life. Additionally, changes in salivary stress markers and antioxidant levels were evaluated.

Results: Of the 50 eligible participants initially enrolled, 45 completed the six-week trial with high compliance (> 80%), including 24 in the PS23 group and 21 in the placebo group. Compared to the placebo group, the PS23 group showed statistically significant improvements in overall insomnia symptoms (group × time interaction, p = 0.011), sleep latency (p = 0.045), sleep maintenance (p = 0.002), and trait anxiety levels (group × time interaction, p = 0.044).

Conclusion: This pilot randomized controlled trial suggests that live L. paracasei PS23 may offer meaningful improvements in sleep quality and anxiety reduction among office workers experiencing elevated stress levels.

Registration: ClinicalTrials.gov Identifier: NCT05826704; registration date: 4/11/2023. Exploring the Effects of Lactobacillus paracasei PS23 on Workplace-related Stress Symptoms Among Office Workers; URL: https://clinicaltrials.gov/study/NCT05826704.

查看原文本刊更多论文

副干酪样乳杆菌PS23对上班族焦虑和睡眠困难的影响：一项双盲、随机对照的试点试验

背景：在过去的十年中，睡眠障碍和压力在普通人群中明显增加。失眠和压力管理不善等状况与一系列身体和心理症状有关，包括心血管疾病、睡眠障碍、抑郁或焦虑。最近的研究表明，经过热处理的副干酪乳杆菌PS23 （PS23）可以缓解临床护士高压力时的焦虑。然而，活的PS23的潜在益处——特别是它对睡眠质量、焦虑和压力的影响——仍未被探索。方法：本研究招募了年龄在20-65岁之间的办公室工作人员，他们报告了中等到高度的感知压力。干预组的参与者连续六周每天服用200亿菌落形成单位的活PS23，而对照组则服用两粒含有微晶纤维素粉的安慰剂胶囊。在基线和试验结束时对结果进行评估，包括压力、焦虑、睡眠质量、疲劳、活动水平、抑郁和整体生活质量。此外，还评估了唾液应激标志物和抗氧化剂水平的变化。结果：在最初入组的50名符合条件的参与者中，45人以高依从性（> 80%）完成了为期6周的试验，其中PS23组24人，安慰剂组21人。与安慰剂组相比，PS23组在整体失眠症状（组×时间相互作用，p = 0.011）、睡眠潜伏期（p = 0.045）、睡眠维持（p = 0.002）和特质焦虑水平（组×时间相互作用，p = 0.044）方面均有统计学显著改善。结论：这项随机对照试验表明，活的副卡萨伊乳杆菌PS23可能对压力高的上班族的睡眠质量和焦虑减少有意义的改善。注册：ClinicalTrials.gov标识符：NCT05826704；报名日期：2023年11月4日。副干酪乳杆菌PS23对办公人员工作压力症状的影响URL: https://clinicaltrials.gov/study/NCT05826704。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Annals of General Psychiatry PSYCHIATRY-

CiteScore

6.60

自引率

2.70%

发文量

审稿时长

>12 weeks

期刊介绍： Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.