Azobenzene-integrated photoresponsive DNA with universal design principles and cross-disciplinary applications: A review

IF 8.5 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Biological Macromolecules Pub Date : 2025-10-09 DOI:10.1016/j.ijbiomac.2025.148159

Chenxi Li , Mengqiu Sun , Rui Song , Zhenshuai Tang , Hao Zhang

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Abstract

Photoresponsive DNA nanotechnology represents an important platform for creating dynamic biomaterials and therapeutic tools. This review presents a systematic approach linking molecular design principles with functional outcomes in azobenzene-DNA systems. Moving beyond previous summaries, we examine key structural features including nucleobase modifications, backbone architectures, and supramolecular organization that govern performance on biological and materials applications. These structural insights explain observed variations in system performance and guide rational design strategies. Recent experimental advances demonstrate practical applications of these principles, particularly in developing infrared-sensitive switches and predictive modeling approaches. The established correlations between molecular structure and functional output provide actionable guidelines for creating more effective light-responsive materials. By bridging fundamental photochemical principles with engineering considerations, this framework facilitates the development of reliable DNA-based systems for biomedical research and nanotechnology applications.

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偶氮苯集成光反应DNA的通用设计原理及其跨学科应用综述。

光反应性DNA纳米技术是创造动态生物材料和治疗工具的重要平台。本文综述了一种系统的方法，将分子设计原理与偶氮苯- dna系统的功能结果联系起来。超越之前的总结，我们研究了关键的结构特征，包括核碱基修饰、主链结构和控制生物和材料应用性能的超分子组织。这些结构见解解释了观察到的系统性能变化，并指导了合理的设计策略。最近的实验进展证明了这些原理的实际应用，特别是在开发红外敏感开关和预测建模方法方面。分子结构和功能输出之间建立的相关性为创造更有效的光响应材料提供了可行的指导方针。通过将基本光化学原理与工程考虑联系起来，该框架促进了用于生物医学研究和纳米技术应用的可靠的基于dna的系统的开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Biological Macromolecules 生物-生化与分子生物学

CiteScore

13.70

自引率

9.80%

发文量

2728

审稿时长

64 days

期刊介绍： The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.