Development and characterization of bioceramic bone cements modified with gold-doped phosphate bioglass

IF 3.9 3区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Journal of Materials Science Pub Date : 2025-09-27 DOI:10.1007/s10853-025-11577-z

Kinga J. Kowalska, Joanna P. Czechowska, Yousef El Sayed, Aneta Zima

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引用次数: 0

Abstract

The development of advanced biomaterials for bone repair addresses critical challenges in regenerative medicine. This study focuses on α-tricalcium phosphate (α-TCP)-based bone cements modified with melt-quenched phosphate bioglasses (P₂O₅–CaO–Ca(OH)₂–KF–TiO₂ and P₂O₅–CaO–Ca(OH)₂–ZnO–KF–TiO₂), doped with 500 and 2000 ppm of HAuCl₄·3H₂O. Gold was introduced as a potential contrast for diagnostic imaging. Bioglass was incorporated into the cement matrix at 10 and 20 wt%, and a bioglass-free cement served as a control. Physicochemical characterization included FTIR, XRD, setting time measurements, compressive strength, in vitro bioactivity evaluation, and chemical stability analysis. Results showed that bioglass addition shortened setting times and increased ion release but disrupted α-TCP hydrolysis, preventing hydroxyapatite formation. Compressive strength decreased due to poor interfacial bonding between α-TCP and bioglass. These findings highlight the need for formulation optimization to balance mechanical integrity, ion release, and bioactivity in bone substitute development.

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掺金磷酸盐生物玻璃改性生物陶瓷骨水泥的研制与表征

用于骨修复的先进生物材料的发展解决了再生医学的关键挑战。本研究的重点是α-磷酸三钙（α-TCP）基骨水泥，用熔融淬火的磷酸盐生物玻璃(P2O5-CaO-Ca （OH) 2-KF-TiO2和P2O5-CaO-Ca (OH) 2-ZnO-KF-TiO2）改性，掺杂500和2000 ppm的HAuCl4·3H2O。黄金被引入作为诊断成像的潜在对比剂。生物玻璃以10%和20%的wt%掺入水泥基质中，不含生物玻璃的水泥作为对照。理化表征包括FTIR、XRD、凝结时间测量、抗压强度、体外生物活性评价和化学稳定性分析。结果表明，生物玻璃的加入缩短了凝固时间，增加了离子释放，但破坏了α-TCP的水解，阻止了羟基磷灰石的形成。α-TCP与生物玻璃界面结合不良导致抗压强度下降。这些发现强调了优化配方以平衡骨替代物发育过程中的机械完整性、离子释放和生物活性的必要性。

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来源期刊

Journal of Materials Science 工程技术-材料科学：综合

CiteScore

7.90

自引率

4.40%

发文量

1297

审稿时长

2.4 months

期刊介绍： The Journal of Materials Science publishes reviews, full-length papers, and short Communications recording original research results on, or techniques for studying the relationship between structure, properties, and uses of materials. The subjects are seen from international and interdisciplinary perspectives covering areas including metals, ceramics, glasses, polymers, electrical materials, composite materials, fibers, nanostructured materials, nanocomposites, and biological and biomedical materials. The Journal of Materials Science is now firmly established as the leading source of primary communication for scientists investigating the structure and properties of all engineering materials.