Dysfunctional vasculogenesis in adipose-derived stem cells from chronic spinal cord injury patients: implications for autologous cell therapy

IF 9.2 1区医学 Q1 PERIPHERAL VASCULAR DISEASE

Angiogenesis Pub Date : 2025-10-10 DOI:10.1007/s10456-025-10012-w

DuJiang Yang, Lin Yang, Junjie Chen, Zihe Wang, Shuang Wang, Jiexiang Yang, GuoYou Wang

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引用次数: 0

Abstract

The recent study by Santos-De-La-Mata et al. (Angiogenesis 28(4): 482025, 2025) provides critical evidence that adipose-derived stem cells (ASCs) from patients with chronic spinal cord injury (SCI) and pressure injuries (PIs) exhibit significantly impaired vasculogenic potential.1 Their comparative analysis revealed deficits in key pro-angiogenic functions, including reduced proliferation, migration, tube formation, and secretion of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in SCI/PI-derived ASCs compared to healthy controls. These in vitro findings were corroborated by a diminished capacity to support neovascularization in an in vivo Matrigel plug assay. This cellular dysfunction underscores a fundamental mechanism contributing to refractory wound healing in this patient population and critically challenges the efficacy of autologous ASC-based therapies. This analysis discusses these findings in the context of chronic inflammatory microenvironments and epigenetic regulation,2,3 and explores potential strategies to overcome this impairment, including allogeneic cell sources4,5 and pre-conditioning techniques to rejuvenate patient-derived cells.6 The work of Santos-De-La-Mata et al. establishes a vital foundation for developing more effective, personalized regenerative medicine approaches for complex chronic wounds.

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慢性脊髓损伤患者脂肪来源干细胞的血管发生功能障碍：对自体细胞治疗的影响

Santos-De-La-Mata等人最近的研究（Angiogenesis 28(4): 482025, 2025）提供了关键证据，证明来自慢性脊髓损伤（SCI）和压力损伤（pi）患者的脂肪来源干细胞（ASCs）表现出明显受损的血管生成潜能他们的比较分析显示，与健康对照相比，SCI/ pi来源的ASCs中关键的促血管生成功能存在缺陷，包括增殖、迁移、管形成以及血管内皮生长因子（VEGF）和肝细胞生长因子（HGF）的分泌减少。这些体外研究结果在体内基质塞实验中证实了支持新生血管的能力下降。这种细胞功能障碍强调了该患者群体难治性伤口愈合的基本机制，并严重挑战了基于自体asc的治疗的有效性。本分析在慢性炎症微环境和表观遗传调控的背景下讨论了这些发现，并探讨了克服这种损伤的潜在策略，包括同种异体细胞来源4,5和预处理技术，以使患者来源的细胞恢复活力Santos-De-La-Mata等人的工作为开发更有效、个性化的复杂慢性伤口再生医学方法奠定了重要基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Angiogenesis PERIPHERAL VASCULAR DISEASE-

CiteScore

21.90

自引率

8.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Angiogenesis, a renowned international journal, seeks to publish high-quality original articles and reviews on the cellular and molecular mechanisms governing angiogenesis in both normal and pathological conditions. By serving as a primary platform for swift communication within the field of angiogenesis research, this multidisciplinary journal showcases pioneering experimental studies utilizing molecular techniques, in vitro methods, animal models, and clinical investigations into angiogenic diseases. Furthermore, Angiogenesis sheds light on cutting-edge therapeutic strategies for promoting or inhibiting angiogenesis, while also highlighting fresh markers and techniques for disease diagnosis and prognosis.