Preparation and Characterization of Nitrogen-Doped Carbon Microspheres for pH-Responsive Colon-Targeted Drug Delivery

IF 8.2 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2025-10-09 DOI:10.1021/acsami.5c10453

Mengcheng Wei, Danlin Zeng, Xiaoling Zhao, Fang Gao, Aoxue Ma

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Abstract

In this study, poly(acrylic acid) (PAA)-coated aspirin (ASA)/amino-N-doped carbon microspheres (P-ASA@ANMCs) were synthesized by a hydrothermal method, amination method, and electrostatic coating method with cassava starch as the carbon source. The design considers both the drug delivery efficiency and biological safety. The microstructure, drug loading capacity, cytotoxicity, antimicrobial activity, and drug release mechanisms were investigated using SEM, FTIR, XRD, Raman spectroscopy, XPS, cell experiments, and antimicrobial testing. The results revealed that the microspheres show a uniform spherical shape (∼1 μm) with a high drug loading capacity. Furthermore, P-ASA@ANMCs exhibited excellent antimicrobial properties against Escherichia coli and Staphylococcus aureus. They also demonstrated pH-responsive colon-targeted sustained-release properties. The detailed release mechanisms were proposed based on characterization data. This study validates the biomedical application potential of cassava-starch-derived microspheres, highlighting the promise of P-ASA@ANMCs for pH-responsive colon-targeted drug delivery systems (pH-CTDDS).

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用于ph响应性结肠靶向药物递送的氮掺杂碳微球的制备与表征

本研究以木薯淀粉为碳源，通过水热法、胺化法和静电包衣法合成了聚丙烯酸（PAA）包被阿司匹林(ASA)/氨基氮掺杂碳微球（P-ASA@ANMCs）。该设计兼顾了给药效率和生物安全性。采用扫描电镜（SEM）、FTIR、XRD、拉曼光谱（Raman spectroscopy）、XPS光谱（XPS）、细胞实验和抗菌测试等方法对其微观结构、载药量、细胞毒性、抗菌活性和药物释放机制进行了研究。结果表明，微球呈均匀的球形（~ 1 μm），具有较高的载药量。此外，P-ASA@ANMCs对大肠杆菌和金黄色葡萄球菌具有优异的抗菌性能。它们还显示了ph响应结肠靶向缓释特性。根据表征数据提出了详细的释放机制。这项研究验证了木薯淀粉衍生微球的生物医学应用潜力，强调了P-ASA@ANMCs在ph响应结肠靶向药物递送系统（pH-CTDDS）方面的前景。

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.