Preparation of AuSe-BNPs/CFME and its high-sensitivity simultaneous detection of caffeic acid and dihydrotanshinone I

IF 13.2 1区工程技术 Q1 ENGINEERING, CHEMICAL

Chemical Engineering Journal Pub Date : 2025-10-10 DOI:10.1016/j.cej.2025.169449

Han Cheng, Yanbing Pan, Tao Fang, Uchkun Ishimov, Awais Ihsan, Abrar Hussain, Ruiting Tian, Wenwen Ma, Jun Li, Xianju Huang

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引用次数: 0

Abstract

Caffeic acid (CA) and dihydrotanshinone I (DHT I) are two important natural products that have become a research hotspot because of their significant antioxidant, anti-inflammatory, and anti-tumour fields. Bimetallic gold‑selenium nanoparticles (AuSe-BNPs) were prepared using the water-bath reduction method, and a carbon fiber microelectrode modified by AuSe BNPs composites (AuSe-BNPs/CFME) was constructed for the detection of CA and DHT I. The electrochemical performance of the AuSe-BNPs/CFME was characterised by using cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS). The good electrical conductivity of AuSe BNPs/CFME was confirmed. CA concentration in the range of 1.0–10.0 μmol/L and DHT I concentration in the range of 0.1–1.0 μmol/L showed a good linear relationship with the oxidation peak currents, and the limits of detection (LODs) of 0.88 μmol/L and 0.0055 μmol/L, respectively. The modified electrode exhibited good anti-interference properties when coexisting with common ions or relevant active ingredients. It was applied to the determination of CA and DHT I in human serum, with recovery rates ranging from 99.1 % to 104.3 %, and can be used for the detection of actual samples.

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aase - bnps /CFME的制备及其对咖啡酸和二氢丹参酮的高灵敏度同时检测

咖啡酸（CA）和二氢丹参酮I （DHT I）是两种重要的天然产物，因其具有显著的抗氧化、抗炎和抗肿瘤作用而成为研究热点。采用水浴还原法制备了双金属金硒纳米粒子（AuSe-BNPs），构建了由AuSe-BNPs复合材料修饰的碳纤维微电极（AuSe-BNPs/CFME），用于检测CA和DHT i。利用循环伏安法（CV）、差分脉冲伏安法（DPV）和电化学阻抗谱（EIS）表征了AuSe-BNPs/CFME的电化学性能。证实了AuSe BNPs/CFME具有良好的导电性。CA浓度在1.0 ~ 10.0 μmol/L范围内和DHT I浓度在0.1 ~ 1.0 μmol/L范围内与氧化峰电流呈良好的线性关系，检出限分别为0.88 μmol/L和0.0055 μmol/L。改性电极与普通离子或相关活性成分共存时表现出良好的抗干扰性能。该法适用于人血清中CA和DHT I的测定，回收率为99.1 % ~ 104.3 %，可用于实际样品的检测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Engineering Journal 工程技术-工程：化工

CiteScore

21.70

自引率

9.30%

发文量

6781

审稿时长

2.4 months

期刊介绍： The Chemical Engineering Journal is an international research journal that invites contributions of original and novel fundamental research. It aims to provide an international platform for presenting original fundamental research, interpretative reviews, and discussions on new developments in chemical engineering. The journal welcomes papers that describe novel theory and its practical application, as well as those that demonstrate the transfer of techniques from other disciplines. It also welcomes reports on carefully conducted experimental work that is soundly interpreted. The main focus of the journal is on original and rigorous research results that have broad significance. The Catalysis section within the Chemical Engineering Journal focuses specifically on Experimental and Theoretical studies in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. These studies have industrial impact on various sectors such as chemicals, energy, materials, foods, healthcare, and environmental protection.